摘要
目的了解乳腺癌患者在接受新辅助化疗前后的癌因性疲乏及生活质量现状以及癌因性疲乏与生活质量的相关性,为临床护理干预提供依据。方法采用方便取样法,对2009年11月至2010年5月北京某肿瘤医院乳腺中心化疗门诊接受新辅助化疗的115名乳腺癌患者,通过Piper疲乏修订量表和简明健康调查问卷进行调查。结果新辅助化疗后患者在疲乏总分[2.4(0,9.0)]、行为[1.7(0,10.0)]、情感[1.8(0,8.4)]、感知[2.2(0,10.0)]、认知情绪[1.8(0,10.0)]四个维度得分均高于化疗前[0(0,8.9),0(0,8.5),0(0,10.0),0(0,9.4),0(0,9.3)],化疗前后比较,差异具有统计学意义(z值分别为-5.874,-5.892,-5.668,-5.712,-5.363;P〈0.01);患者的生活质量各维度(除精神健康外)得分与新辅助化疗前的得分比较差异均有统计学意义(P〈0.01);化疗后疲乏与生活质量的精力、情感职能、生理职能、社会功能、精神健康、-般健康状况、生理机能等7个维度得分呈负相关,表现在患者随着疲乏的加重,得分呈降低趋势。结论新辅助化疗会导致乳腺癌患者出现癌因性疲乏,同时新辅助化疗所导致的癌因性疲乏会影响乳腺癌患者的生活质量,因此,采取有效的干预措施减轻患者的疲乏以提高患者的生活质量是非常有必要的。
Objective To describe the status of cancer-related fatigue and quality of life of breast cancer patients before and after neoadjuvant chemotherapy and provide the evidence for the clinical intervention. Methods The convenient sample was utilized. Totals of 115 breast cancer patients who received the neoadjuvant chemotherapy between November 2009 and May 2011 were investigated with the revised Piper fatigue scale Chinese version and Short Form 36 Health Survey Questionnaire. Results The total score of cancer-related fatigue, dimensions scores of total score of fatigue [ 2.4 (0,9. 0) ], behavior [ 1.7 ( 0,10. 0) ], emotion [ 1.8 (0,8.4) 1, perception [ 2.2 (0,10. 0) ], and cognitive emotion [ 1.8 (0,10. 0) ]of patients after neoadjuvant chemotherapy were significantly higher than that of before neoadjuvant chemotherapy [ 0 (0,8.9), 0 (0,8.5), 0 (0,10.0), 0 (0,9.4), 0 (0,9.3)] (Z= -5.874, -5.892, -5.668, -5.712, -5.363, respectively;P 〈0.01 ). Before and after neoadjuvant chemotherapy,significant difference was detected in the quality of life (P 〈 0. O1 ). Cancer - related fatigue was negatively correlated with the quality of life of patients and its aspects of mental health, physical functioning, role-function, general health, vitality, social functioning, role-emotional. Conclusions Neoadjuvant chemotherapy can result the cancer-related fatigue, and cancer-related fatigue can influence the patients' life quality. Therefore, it is necessary to apply the effective intervention in order to alleviate cancer-related fatigue and improve their life quality.
出处
《中华现代护理杂志》
2012年第29期3481-3484,共4页
Chinese Journal of Modern Nursing
关键词
乳腺肿瘤
新辅助化疗
癌因性疲乏
生活质量
Breast cancer
Neoadjuvant chemotherapy
Cancer related fatigue
Quality of life