摘要
目的探讨纳洛酮联合银杏达莫对肺源性心脏病急性加重期患者血浆脑钠肽（BNP）和内皮素-1（ET-1）的影响。方法80例肺源性心脏病急性加重期患者随机分为治疗组40例和对照组40例，对照组采用一般常规治疗，治疗组在常规治疗的基础上加用纳洛酮和银杏达莫，两组共治疗10d。比较治疗前后两组患者的动脉血氧分压（PaO：）、动脉血二氧化碳分压（PaC02）和静息状态下平均肺动脉压（mPAP）；比较两组患者BNP和ET-1浓度变化。结果两组治疗后PaO：均有升高，治疗纽升高幅度优于对照组，差异有统计学意义（P〈0．05）；两组PaCO，均有下降，治疗组优于对照组（P〈0．05）；两组治疗后mPAP均有下降，且治疗组降低幅度优于对照组，差异有统计学意义（P〈0．05）；两组治疗后都可明显降低血浆BNP和ET-1的含量，但治疗组降低程度优于对照组（P〈0．05）。结论纳洛酮联合银杏达莫改善肺源性心脏病急性加重期患者的病情，可能与改善患者的BNP和ET-1有关。
Objective To investigate the effect of naloxone combined with ginkgo bilobate ex-tract on the brain natriuretic peptide （BNP）and endothelin-1 （ ET-1 ） in the plasma of patientswith pulmonary heart disease. Methods Eighty patients with pulmonary heart disease were randomly di- vided into two groups, the control group （n = 40） and the treatment group （n = 40）. Patients in the control group were treated with conventional treatment, while patients in the treatment group were addi- tionaly given naloxone combined with ginkgo bilobate extract. The subjects were treated for ten days. Re- suits Compared with the control group, the PaO2 was significantly improved （P 〈 0.05 ）. PaCO2 and mPAP were more significantly reduced in the treatment group than those in the control group （P 〈 0.05 ）. The plasma levels of BNP and ET-1 were significantly decreased after treatment in both groups, especially in the treatment group （P 〈 0.05 ）. Conclusions Naloxone combined with ginkgo bilobate extract could improve the conditions of pulmonary heart disease, which are related with the reduction of BNP and ET-1.
出处
《中国实用医刊》
2012年第22期37-39,共3页
Chinese Journal of Practical Medicine
关键词
肺源性心脏病
纳洛酮
银杏达莫
脑钠肽
内皮素-1
Pulmonary heart disease
Naloxone
Ginkgo bilobate extract
Brain natriuretic pep-tide
Endothelin-!
