摘要
目的评估饲料品质、供应风险及价格,为24个月长期致癌性试验寻找最佳的饲料及饲料供应商。方法将日本进口MF18饲料,美国进口LabDiet饲料以及北京科澳生产的啮齿类饲料样品分别包装,委托专业检测实验室对常规营养成分、毒理及微生物指标进行检测,评估饲料品质;对各来源饲料的运输风险、非可控因素等可能影响饲料品质及稳定供应的方面进行评估;兼顾饲料价格作为参考评估因素。结果经评估,3种饲料品质均符合饲料国标GB14924-2001*的要求;以毒性研究关注的毒理指标作为评价标准,则3种饲料品质排序为:MF18饲料(最佳)—>LabDiet饲料(较佳)—>科澳国产饲料(佳);进口饲料的运输及供应稳定性相比存在较大风险;国产饲料价格相对便宜但未成为关键评估因素。结论经过综合评估,特殊定制的本地国产饲料被认定为是国家药物安全评价监测中心24个月致癌性试验用的最佳饲料。
Objective To find the best feed and feed supplier for 24-month rodent carcinogenicity studies by assessing the quality,supply risks and price of three rodent feeds.Methods Samples of the MF18 feed（Japan）,LabDiet feed（USA） and SPF domestic rodent feed（Beijing） were sent to a professional laboratory for testing the conventional nutrients,metals and pesticides,and microbiological indicators,and to evaluate the quality of the feeds.Risks on feed transport and non-controllable factors which might affect feed quality and supply were evaluated.The price of each feed as a reference factor was also considered.Results The quality of the three feeds met the requirements of standard GB14924-2001.According to the evaluation criteria for general toxicological indicators concerned in toxicity studies,the quality sort of the three feed was ranked as： MF18 feed（the best）- LabDiet feed（better）- local feed produced in Beijing（good）.There were significant risks in transportation and supply for the imported feeds.The price of the domestic feed was relatively cheap but was not considered as a critical factor.Conclusions After a comprehensive comparison,the special customized domestic feed is selected for the 24-month carcinogenicity study to be conducted in the National Centre for Safety Evaluation of Drugs.
出处
《中国比较医学杂志》
CAS
2012年第10期46-49,共4页
Chinese Journal of Comparative Medicine
