摘要
目的观察感染后慢性咳嗽患者气道分泌物神经肽变化,探讨其可能的发病机制。方法选择感冒后慢性感染患者32例作为观察组,另选择30例健康成人作为对照组,对比两组痰细胞分类及SP、NKA、NKB浓度。结果两组痰细胞分类比较,观察组白细胞、中性粒细胞、巨噬细胞、嗜酸性粒细胞、淋巴细胞与对照组比较,差异均无统计学意义(P>0.05);观察组治疗前SP为(508.7±154.8)ng/L,治疗后为(152.4±56.4)ng/L,对照组为(143.5±35.1)ng/L,观察组治疗前SP表达高于治疗后及对照组(P<0.01)。结论感染后慢性咳嗽患者伴随有气道神经源性炎症介质SP的升高,提示其与感染后慢性咳嗽的发病密切相关。
Objective To observe the change of neuropeptide of the patients with PI chronic cough and explore the possible pathogenesis.Methods Thirty-two cases with PI chronic cough in our hospital were selected as observation group,while 30 health adults cases as control group. Phlegm cells classification and SP,NKA,NKB concentration of the patients in both groups were compared.Results Phlegm cells classification of the two groups shows that,compared with the control group, the white blood cells,neutrophils,macrophages,eosinophils and lymphocytes of the patients in the observation group have no statistical significance.（P0.05）.Before treatment,the SP of the patients in the observation group was （508.7±154.8）ng/L,and （152.4±56.4）ng/L after treatment; while the SP of the patients in the control group was（143.5±35.1）ng/L.The SP expression of the patients in the observation group before treatment was higher than after treatment and that of the control group（P0.01）.Conclusion The increase of SP in the patients with PI chronic cough mentions that it is closely related to the PI chronic cough.
出处
《白求恩军医学院学报》
2012年第5期373-374,共2页
Journal of Bethune Military Medical College
