摘要
双特异性抗体(bispecific antibody,BsAb)是具有两个抗原结合位点,可选择性募集效应细胞到靶细胞周围,介导特异性杀伤作用的新型抗体。BsAb由两条不同的重链和轻链组成,可分别结合到呈现不同细胞类型的两个抗原上(靶细胞表面抗原,载荷物如效应细胞)。近年来,随着国内外BsAb的相关研究的飞速发展,因BsAb在疾病诊治中的作用逐渐丰富而受到广泛关注。本文就BsAb的临床应用及研究新进展作一综述。
The bispecific antibody is a novel antibody,which has 2 antigen binding sites,and it can mediate specific killing effect by selectively raising the effector cells to the surrounding of target cells.BsAb is composed of 2 different chains： the heavy chain and the light chain,which can bind to 2 antigens showed different cell types respectively（target cell surface antigen,load such as effector cells）.With the rapid development of research at home and abroad in recent years,BsAb was gradually attracted widespread attention to its use in diagnosis and treatment.The clinical applications and new development of BsAb were reviewed in this paper.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第10期971-974,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
双特异性抗体
肿瘤治疗
免疫性疾病
干细胞移植
Bispecific antibody
Cancer treatment
Autoimmune diseases
PET
Stem cell transplantation
