摘要
目的:探讨血小板表面纤维蛋白原受体(FIBR)、P-选择素(CD62P)表达水平与脑梗死的关系,为脑梗死的预防与治疗提供依据。方法:脑梗死患者62例(A组),脑梗死高危患者56例(B组),健康体检者40例(C组),A组在发病第3～5天药物治疗前,B、C组于清晨空腹采血2ml,采用流式细胞仪测定周围血中FIBR、CD62P的表达;A组患者再进行颈部超声检测,观察血管有无斑块形成。结果:经检测,A、B组FIBR和CD62P的表达均明显高于C组(P<0.01),且A组更高于B组(P<0.05)。A组中有颈动脉粥样硬化组FIBR、CD62P水平显著高于无颈动脉粥样硬化组(P<0.05)。结论:血小板膜蛋白FIBR、CD62P有望成为预测高危患者发生脑梗死和指导脑梗死抗血小板治疗的敏感指标。
Objective：To study the relationship between the expression of platelet membrane proteins（fibrinogen receptor, FIBR; P-selectin,CD62P）and ischemic stroke in order to provide the medical basis for prevention and treat- ment of ischemic stroke. Methods：There were 62 cases in ischemic stroke group（group A）and 56 cases in high-risk group of ischemic stroke（group B）. Forty healthy volunteers served as control group. The platelet membrane FIBR and CD62P expression in peripheral blood was detected by using flow cytometry. Blood （2ml） was drawn from each patient before treatment at third to fifth day after the attack in group A,and in groups B and C fasting blood （2ml） was drawn in the morning. Results： The FIBR and CD62P expression levels in groups A and B were significantly higher than in group C（P〈0.01） ,and those in group A were higher than in group 13（P〈0.05）. In group A,the ex- pression levels of FIBR and CD62P in patients with carotid atherosclerosis were higher than in those without carotid atherosclerosis（P〈0.05）. Conclusion：The platelet membrane protein FIBR and CD62P may be regarded as sensitive indexes for forecasting stroke and conducting anti-platelet treatment.
出处
《中国康复》
2012年第5期330-332,共3页
Chinese Journal of Rehabilitation
基金
武汉市科技攻关项目(No 201060938360-05)
