摘要
目的 探讨肿瘤坏死因子 -a(TNF -a)、去甲肾上腺素 (NE)、内皮素 (ET)、肾上腺髓质素 (ADM)在全身炎症反应综合征 (SIRS)病理过程中的作用。方法 检测 38例不同类型的SIRS(创伤、创伤性休克、感染性休克 )患者及 12例健康对照组血浆TNF -a、NE、ET、ADM水平。结果 创伤组、创伤性休克组、感染性休克组与正常对照组血浆TNF -a、NE、ET、ADM浓度相比均明显增加 ,尤以感染性休克组为明显 (P <0 0 1)。结论 TNF -a、NE、ET、ADM可能参与SIRS的病理过程。
Objective To investigate the role of tumor necrosis factor-a(TNF-a),norepinephrine (NE),endothelin (ET),adrenomedullin(ADM)in the pathogenesis of systemic inflammatory response syndrome(SIRS).Methods Plasma TNF-a,NE,ET and ADM levels were measured in 38 patients with SIRS .Results Plasma TNF-a,NE,ET and ADM levels were significantly higher in SIRS,especically in sepsis shock than that of healthy controls ( P <0 01) Conclusion The results indicate that TNF-a,NE,ET and ADM plays an important role in the pathophysiology of SIRS. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2000年第7期398-399,共2页
Chinese Journal of Critical Care Medicine
