摘要
[目的]了解近年上海市闵行区志贺菌菌群分布和耐药性特点,为细菌性痢疾的临床合理用药和疾病预防控制工作提供科学依据。[方法]对2007—2009年该区各肠道门诊监测点腹泻病人的肛拭标本进行细菌分离培养、鉴定和血清分型,并用改良纸片扩散法法进行药物敏感试验。[结果]251株志贺菌中,B群福氏志贺菌180株、D群宋内志贺菌71株,未分离出其他群型的志贺菌;251株志贺菌对四环素、复方新诺明、氨苄西林、利福平和萘啶酸耐药明显,均>76.00%,对环丙沙星、阿莫西林相对比较敏感,但B群与D群之间差异具有统计学意义;3年间,庆大霉素等药物的耐药性有所递增。[结论]该区志贺菌菌群具有较高的耐药性,且部分药物的耐药性有逐年递增的趋势,应加强耐药性监测和疾病防治。
[ Objective ] To investigate the distribution of serotypes and the resistance rate of Shigella in Minhang District of Shanghai, and to provide scientific basis for choosing proper antibacterial drugs and for Shigellosis prevention.and control. [ Methods ] The anus probe samples of diarrhea patients from intestinal disorders out-patient monitoring sites were collected between 2007 and 2009 for bacteria isolation, culturing and serotype identification. At the same time, antibiotic sensitivity test was performed by modified disk diffusion method. [ Results ] A total of 251 strains of Shigella were cultured from 2007 to 2009, including 180 Shigellaflexneri strains and 71 Shigella sonnei strains, while no other serotype of Shigella was found. The Shigella specimens presented a high rate of resistance to tetracyclin, sufisomezde/trimethylolpropane, ampicillin, rifampicin, and nalidixic acid, all greater than 76%; but a low rate of resistance to ciprofloxacin and amoxicillin. The two species had a striking difference in their resistant rates. The rate of resistance to gentamicin was increased from 2007 to 2009. [ Conclusion ] The resistance rates in Shigella are high in the district studied, and the rates to part of the antimicrobial agents are increased from 2007 to 2009. More attention should be paid to the surveillance and control of such resistance.
出处
《环境与职业医学》
CAS
北大核心
2012年第10期652-654,共3页
Journal of Environmental and Occupational Medicine
关键词
福氏志贺菌
宋内志贺菌
耐药性
抗菌药物
Shigella flexneri
Shigella sonnei
antibiotic resistance
antimicrobial agent
