期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

子宫腺肌病病灶中微血管密度及水通道蛋白1的表达 被引量：4

暂未订购
导出
摘要 目的:检测子宫腺肌病病灶组织中微血管密度(MVD)及水通道蛋白1(AQP1)的表达,探讨AQP1在子宫腺肌病发病机制中的作用。方法:选择行子宫切除或子宫腺肌病腺肌瘤切除的25例患者(子宫腺肌病组)和25例正常子宫内膜(对照组)为研究对象,采用CD34免疫组织化学染色法检测子宫腺肌瘤组织中MVD和Western Blot检测其AQP1相对积分光密度值(OD)进行蛋白定量。结果:子宫腺肌病组腺肌瘤组织中MVD值57.21±14.95个/HP(每高倍视野),明显高于对照组25.07±11.76个/HP,差异有高度统计学意义(t=10.124,P=0.001)。子宫腺肌病组腺肌瘤中AQP1表达强度OD值0.7957±0.2039明显高于对照组OD值0.6629±0.1931,差异有高度统计学意义(t=10.452,P=0.000)。结论:AQP1在子宫腺肌瘤组织中的高表达与其MVD增高相一致,推测AQP1可能参与腺肌瘤中微血管的形成,其高表达可能是子宫腺肌病形成的原因之一。
作者 廖百花
机构地区 广东省第二人民医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2012年第9期775-777,共3页 Journal of Practical Obstetrics and Gynecology
基金 广东省医学科研基金资助(编号:A2011128)
关键词 子宫腺肌病 微血管密度 水通道蛋白1 新生血管形成
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献10

  • 1Mclarn J,Vascular endothelial growth factor and endometriotic angio- genesis [ J ]. Hum Update,2000,6 ( 1 ) :44 - 45.
  • 2Mints M, Hildenbrand A, Lalitkumar LP, et al. Expression of aquapor- in 1 in endometrial blood vessels in menorrhagia[ J]. Int J Mol Med, 2007,19(3) :407 -411.
  • 3高晓葳,黄永旺,刘静.水通道蛋白1和血管内皮生长因子在喉鳞状细胞癌组织中的表达及相关性研究[J].临床耳鼻咽喉头颈外科杂志,2009,23(9):407-410. 被引量：6
  • 4Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis : a new sig- nificant and independent prognostic indicator in early-stage breast car-cinoma[ J]. J Nail Cancer Inst,1992,84(24) : 1875 - 1887.
  • 5张晓玲,王爽,朱清仙.血管内皮生长因子在卵巢子宫内膜异位症组织中的表达及其临床意义[J].中国体视学与图像分析,2009,14(4):333-337. 被引量：3
  • 6Feng D, Welker S, Korbel C, et al. Protein kinase CK2 is a regulator of angiogenesis in endometriotic lesions [ J]. Angiogenesis, 2012,15 (2) :243 -252.
  • 7Xu H, Becker cm, Lui WT, et al. Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signa- ling in experimental endometriosis in vivo [ J ]. Fertil Steril, 2011,96 (4) :1021 - 1028.
  • 8Krikun G, Hu Z, Osteen K, et al. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of en- dometriosis[ J]. Am J Patho1,2010,176(2) : 1050 - 1056.
  • 9Verkman AS, Hara-Chikuma M, Papadoponlos MC. Aquaporins-new players in cancer biology[ J ]. J Mol Med,2008,86 (5) :523 - 529.
  • 10Saadoun S, Papadopanlos MC, Hara-Chikuma M, et al. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disrup- tion [ J ]. Nature, 2005,434 ( 7034 ) :786 - 792.

二级参考文献22

  • 1王含必,郎景和,冷金花,朱兰,刘珠凤,孙大为.血管内皮细胞生长因子受体在子宫内膜异位症中表达的研究[J].中华医学杂志,2005,85(22):1555-1559. 被引量：7
  • 2吴建红,陕光,张端莲,叶庆斌,郑承庆,熊烈.川芎嗪治疗后肝纤维化组织中I型胶原平均光密度表达的比较[J].数理医药学杂志,2006,19(2):134-135. 被引量：10
  • 3郎景和.子宫内膜异位症研究的任务与展望(之一)[J].中华妇产科杂志,2006,41(5):289-290. 被引量：125
  • 4NEUFELD G, TESSLER S, GITAY-GOREN H,et al. Vascular endothelial growth factor and its recep tors[J]. Prog Growth Factor Res, 1994,5: 89-97.
  • 5MATTERN J, KOOMAGI R, VOLM M. Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumor cell proliferation in human epidermoid lung carcinoma[J]. Br J Cancer, 1996,73: 931- 934.
  • 6ITOH T,RAI T,KUWAHARA M,et al. Identification of a novel aquaporin, AQP12, expressed in pan creatic acinar cell [J]. Biochem Biophys Res Commum, 2005,330 : 832 - 838.
  • 7KING L S,KOZONO D,AGRE P. From structure to disease: the evolving tale of aquaporin biology[J]. Nat Rev Mol Cell Biol,2004,5:687-698.
  • 8ALTUNTAS A, YILMAZ M D, AKTEPE F,et al. Expression and distribution of aquaporin-1 in nasal polyps: does it have any significance in edema forma tion[J]? Am J Rhinol,2006,20:128-131.
  • 9YANGJ H, SHIYF, CHENXD, et al. Theinfluence of aquaporin-1 and microvessel density on ovari an carcinogenesis and ascites formation[J]. Int J Gynecol Cancer, 2006,16(Suppl 1):400-405.
  • 10HU J, VERKMAN A S. Increased migration and metastatic potential of tumor cells expressing aqua porin water channels[J]. FASEB, 2006,20: 1892-1894.

共引文献7

同被引文献37

  • 1詹才芳,申爱荣.子宫腺肌病中细胞凋亡和增殖状况及其相关基因表达研究[J].实用诊断与治疗杂志,2005,19(5):322-323. 被引量：5
  • 2Mcl,ARN J. Vascular endothelial growth factor and endometriotic angiogenesis[ J]. Hum Update, 2000, 6( I ) : 44 -45.
  • 3FUJIMOTO J, SAKAGUCHI tt, ttlROSE R, el al. Angiogenesis in endometriosis and angiogenic factors [ J ]. Gyanecol Obstet In- vest, 1999, 48 Suppl 1 : 14 -20.
  • 4GUIDI A J, ABU JAWDEH G, TONGNAZZI K, et al. Expressinn of vascular pernleability factor( vascular endothelial growth factor) and its receptors in endometrial carcinoma[ J ]. Cancer, 1996, 78 ( 3 ) : 454 - 460.
  • 5SAAI)OUN S, PAPADOPANLOS M C, HARA CH1KUMA M, et al. Impairment of angiogenesis and cell migration by targeted aquaporin - I genedisruption[J]. Nature, 2005, 434(7034) : 786 -792.
  • 6WEIDNER N, FOLKMAN J, POZZA F, et al. Tumor angiogenesis: a new sit.,naificant and independent prognostic indicator in early -stage reasl carcinoma [ J ] . J Natl Cancer In,st, 1992, 84 (24) : 1875 - 1887.
  • 7PARK R, CHANG C C, LIAN(; Y C, et al. Systemic tatmenl with tetra - O - methyl nordihydtxJguaiaretie acid suppresses the g'owth of hunmn xenografl tmnors[ J ]. Clin Cancer Res, 2005, 11 ( 12 ) : 4601 - 4609.
  • 8GROOTHUIS P G, NAP A W, WINTERHAGER E, et al, Vascu- lar development in endometriosis [ J ]. Angionenesis, 2005 ( 8 ) : 147 - 156.
  • 9MASUDA H, MARUYAMA T, HIRATSU E, et al. Noninvasive and real - time assessment of reconstructed tunctional human endo- metrium in NOD/SCID/gamma c ( null ) inmmnodeficient mice [J]. Proc Natl Acad Sci U S A, 2007, 104(6) : 1925 - 1930.
  • 10Jie Zhou,Tobias Schmid,Steffen Schnitzer,Bernhard Brüne.Tumor hypoxia and cancer progression[J].Cancer Letters.2005(1)

引证文献4

二级引证文献25

实用妇产科杂志
2012年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部