摘要
目的:评估HIV母婴阻断效果,为预防艾滋病母婴传播工作提供借鉴。方法:在围生期门诊为初次建卡产前检查的孕妇检测抗-HIV,为HIV感染孕妇提供综合性母婴阻断措施,临产前采血检测HIV病毒载量,对婴儿HIV感染状况进行随访,即产后4月内2次为婴儿采血检测HIV-DNA,12、18月龄时再次检测抗-HIV。结果:近4年来该院孕妇HIV感染率为0.28%,经采取综合性母婴阻断措施,孕期进行规范三联抗病毒治疗,82.71%的孕妇临产时病毒载量低于最低检测限,婴儿HIV感染率0.75%,明显低于未治疗者之婴儿(感染率25.00%),差异有统计学意义(P<0.05)。结论:为HIV感染孕妇实施综合性母婴阻断措施安全有效,不失为预防艾滋病母婴传播的有利措施。
Objective：To evaluate the effectiveness of blocking of HIV maternal-neonatal transmission,and provide reference for preventing maternal-neonatal transmission of HIV. Methods：HIV antibodies were detected in the pregnant women who registered and received prenatal examination for the first time in perinatal outpatient department,then comprehensive blocking measures of maternal-neonatal transmission of HIV were provided to HIV-infected pregnant women,HIV load was detected in labor,the HIV infection status of infants was followed up： HIV DNA of infants were detected twice within four months after birth,HIV antibodies were detected at 12 and 18 months. Results：In recent four years,the infection rate of HIV in pregnant women from the hospital was 0.28%.After comprehensive blocking measures of maternal-neonatal transmission of HIV and regular triple antiviral therapy during pregnancy period,the viral load of 82.7% of the pregnant women in labor was lower than the lowest detection limit;the infection rate of HIV in infants was 0.75%,which was statistically significantly lower than that in infants without treatment（25.00%）（P〈0.05）. Conclusion：Comprehensive blocking measures of maternal-neonatal transmission of HIV are safe and effective for HIV-infected pregnant women,which are forceful measures for preventing maternal-neonatal transmission of HIV.
出处
《中国妇幼保健》
CAS
北大核心
2012年第30期4683-4686,共4页
Maternal and Child Health Care of China
关键词
HIV感染孕妇
母婴阻断
效果
HIV-infected pregnant women
Blocking of maternal-neonatal transmission
Effectiveness
