摘要
转录因子FOXO3a是Forkhead家族的一个重要成员,作为人体内七大神秘基因之一,广泛参与细胞的信号转导、生长发育、凋亡及抗氧化应激,并具有延长寿命的作用。FOXO3a是广为人知的抑癌基因,其作用包括促进细胞凋亡、抑制血管生成等。然而,近年来发现慢性粒细胞性白血病干细胞依赖于FOXO3a,这一颠覆性的研究结果促使人们重新认识FOXO3a——这个神秘的转录因子。
FOXO3a is an important transcriptional factor of the Forkhead family. As one of the seven mysterious genes, FOXO3a participates in multiple signaling pathways, and is involved in cell growth, development, apoptosis, oxidation stress, etc.. FOXO3a is a well-known tumor-suppressor gene, its action including promoting cell apoptosis and inhibiting angiogenesis. However, in recent years, it has been demonstrated that FOXO3a plays an essential role in the maintenance of leukaemia-initiating cells which drive the recurrence of chronic myeloid leukemia （CML）, suggesting that FOXO3a may have multiple functions beyond our imagination.
出处
《生命的化学》
CAS
CSCD
2012年第5期447-451,共5页
Chemistry of Life
基金
国家自然科学基金项目(81172506)
上海市乳腺肿瘤重点实验室建设项目(12DZ2260100)资助
