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USP22在转录调控及肿瘤发生中的作用 被引量：1

Roles of USP22 in transcriptional regulation and tumorogenesis
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摘要 泛素特异性蛋白酶22(ubiquitin specific protease 22,USP22)是一种组蛋白去泛素化酶,在核受体介导的基因转录调控中起增强转录活性的作用。USP22在肿瘤发生、发展中发挥着重要作用,影响癌基因c-Myc介导的基因转录,从而促进肿瘤的增殖和生长;另一方面,USP22可改变远上游识别序列结合蛋白1(far upstream element-binding protein 1,FBP1)的泛素化水平,从而影响FBP1下游的抑癌基因p21的表达。USP22与胃癌、大肠癌、乳腺癌及膀胱癌等肿瘤的病理进程相关。此外,USP22在端粒稳态的维持中起作用。本文主要综述USP22参与核受体介导的基因转录调控的表观遗传学机制及其在肿瘤发生中的作用。 Ubiquitin specific protease 22 （USP22）, a histone deubiquitinase, mediates the histone H2A and H2B deubiquitinatin and coactivates ligand-dependent nuclear receptor-mediated transactivation. USP22 plays an important role in tumorogenesis and development. USP22 modulates c-Myc-induced transcription to facilitate tumor proliferation and growth. On the other hand, USP22 alterates the ubiquitination level of far upstream element-binding protein 1 （FBP 1）, leading to inhibition of the expression of p21. USP22 is also closely related to the pathological process of gastric carcinoma, colorectal cancer and invasive breast cancer. Moreover, USP22 plays a role in telomere maintenance. This paper will review the epigenetic mechanisms of USP22 involved in nuclear receptor-mediated transcriptional regulation and the role of USP22 in tumorogenesis.
作者 刘琪 王胜利 赵越
机构地区 中国医科大学基础医学院细胞生物学系 卫生部细胞生物学重点实验室暨教育部医学细胞生物学重点实验室染色质生物学研究室
出处 《生命的化学》 CAS CSCD 2012年第5期400-403,共4页 Chemistry of Life
基金 国家自然科学基金项目(30871390 31171259 31271364) "973"国家重大科学研究计划(2013CB945200)资助
关键词 USP22 转录调控 表观遗传学机制 肿瘤的发生发展 USP22 transcriptional regulation epigenetic mechanism tumor development
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

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同被引文献15

  • 1王克文,张桂英.食管癌Survivin mRNA、Caspase-3的表达及其分子机制[J].医学临床研究,2005,22(7):896-898. 被引量：1
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  • 3Zhang XY, Varthi M, Sykes SM,et al. The putative canc- er stern cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression[J]. Mol Cell, 2008, 29(1): 102.
  • 4Atanassov BS, Evrard YA, Multani AS, et al. Gcn5 and SAGA regulate sheherin protein turnover and telomere ma- intenance[J]. Mol Cell, 2009, 35(3): 352.
  • 5Li J,Wang Z, Li Y. USP22 nuclear expression is signifi- cantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma [J]. J Cancer Res Clin Oncol. 2012. 138(8). 1291.
  • 6Wang W, Xue L, Wang P. Prognostic value of beta-cate- nin, c-myc, and cyclin D1 expressions in patients with e- sophageal squamous cell carcinoma[ J]. Med Oncol,2011 , 28(1) :163.
  • 7Gomes TS, Noguti J, Forones NM, et al. Correlation anal- ysis of c-myc, p21 ( WAF/CIPI ) , p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma [J]. Pathol Res Pratt,2013,209(1):6.
  • 8Jiang I-I, Gong M, Cui Y, et al. Upregulation of caspase-3 expression in esophageal cancer correlates with favorable prognosis: an immunohistochemieal study from a high inci- dence area in northern China[J]. Dis Esophagus ,2010,23 (6) :487.
  • 9王涛,侯桂琴.食管鳞状细胞癌组织中Survivin与Caspase-3蛋白的表达[J].郑州大学学报（医学版）,2010,45(3):362-365. 被引量：5
  • 10陈廷福,金先庆,杨坤,赵丽华.丙泊酚、神经节苷脂对幼鼠认知和caspase-3表达的影响[J].解放军医学杂志,2010,35(7):845-848. 被引量：10

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生命的化学
2012年 第5期

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