摘要
肿瘤细胞多药耐药性(multidrug resistance,MDR)的产生是临床上导致肿瘤化疗失败的主要原因之一,因此寻找高效低毒的MDR逆转剂已成为肿瘤药物开发领域的热点。MDR的作用机制主要包括P-糖蛋白、多药耐药相关蛋白、乳腺癌耐药蛋白、肺耐药相关蛋白等等。多药耐药逆转剂包括钙离子通道阻滞剂、维拉帕米及其衍生物等等。本文主要介绍了MDR的作用机制以及肿瘤多药耐药逆转剂的研究进展。
Multidrug resistance （MDR） is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors. Searching for highly effective and lowly toxic reversal agents for MDR is a hot field in regard to cancer drug development. The mechanisms of MDR mainly include P-glycoprotein, muhidrugresistance-associated protein, breast cancer resistance protein, lung resistant-related protein, etc.. MDR reversal agents include calcium channel blockers, Verapam and its derivative, etc.. This paper mainly introduces the mechanisms of MDR and the development of MDR reversal agents.
出处
《生命的化学》
CAS
CSCD
2012年第5期395-399,共5页
Chemistry of Life
基金
国家"973"项目(2010CB833804)
国家"863"项目(2011AA09070110)资助
