摘要
目的研究维生素D与子痫前期的相关性。方法选取行产前检查的孕妇442例，分为正常对照组420例和子痫前期组22例，分别在孕10-14周和孕24-28周采集血清，检测血清25羟基维生素D[25（OH）D]含量并比较，应用Logistic回归分析血清25（OH）D含量与子痫前期的关系。结果孕24～28周正常对照组和子痫前期组血清25（OH）D含量分别为（56-3±18．8）nmol／L和（46．2±17．4）nmol／L，差异有统计学意义（P〈0．01）。孕24～28周血清25（OH）D含量与子痫前期发病具有相关性，校正后OR值为0．67，P=0．01，回归系数为-0．3910，Wald值为12．3174。结论孕24—28周血清25（OH）D含量与子痫前期发病具有相关性。
Objective To study the relationship of Vitamin D and preeclampsia. Methods Four hundred and forty-two pregnant women were enrolled in this study, they were divided into two groups, 420 women without preeclampsia （control group） and 22 women with preeclampsia （preeclampsia group）. Blood serum was collected during the 10th-14th and 24th-28th week of gestation, 25-hydroxyvitamin D [25（OH） D] was detected. The level of 25 （ OH ） D was compared between two groups and Logistic regression analysis was used to investigate the association of 25 （OH） D and preeelampsia. Results The level of 25 （OH） D at 24th-28th week in control group [ （56.3 ± 18.8 ） nmol/L] was significantly higher than that in preeclampsia group [（46.2 ± 17.4） nmol/L] （P 〈0.01）. The level of 25 （OH） D had significant relationship with preeclampsia at 24th-28th week （OR =0.67,P =0.01）, regression coefficient was -0.3910, Wald was 12.3174. Conclusion The level of 25 （OH） D is associated with preeclampsia at 24th-28th week of gestation.
出处
《中国医师进修杂志》
2012年第30期4-5,共2页
Chinese Journal of Postgraduates of Medicine
