摘要
目的:观察阻塞性睡眠呼吸暂停低通气综合征患者血清中IFN-γ和IL-4的变化。方法:采用ELISA法检测阻塞性睡眠呼吸暂停低通气综合征患者及无创呼吸机辅助通气配合针灸方法治疗后患者血清中IFN-γ和IL-4的含量。结果 :OSAHS患者血清中IFN-γ较正常组显著升高(P<0.01),而IL-4含量较正常组显著降低(P<0.01);经过无创呼吸机辅助通气配合针灸治疗后IFN-γ较OSAHS组显著降低(P<0.05),而IL-4含量较OSAHS组明显增高(P<0.05)。结论:OSAHS患者存在Th1/Th2亚群比例的失衡,这可能是OSAHS的发病机制之一。
Objective：To observe the serum levels changes of IFN-γ and IL-4 in obstructive sleep apnea syndrome patients.Methods：ELISA was used to detect serum levels of IFN-γ and IL-4 in obstructive sleep apnea hypopnea syndrome patients as well as in the patients treated by noninvasive mechanical ventilation method.Results：The serum level of IFN-γ in OSAHS patients was significantly higher than that in the normal group（P0.01）,while IL-4 level was significantly lower（P0.01）than that in normal group;while the serum level of IFN-γ in OSAHS patients was significantly decreased（P0.05）,and IL-4 level was significantly increased（P0.01）after the non-invasive mechanical ventilation treatment.Conclusion：Th1/Th2 subsets imbalance existed in OSAHS patients,this might be one of the mechanisms of OSAHS.
出处
《辽宁中医药大学学报》
CAS
2012年第11期189-190,共2页
Journal of Liaoning University of Traditional Chinese Medicine
