摘要
目的探讨磁共振扩散加权成像(diffusion weighted imaging,DWI)在鼻咽癌调强放射治疗中的临床应用价值。方法回顾性分析经病理检查证实的60例初诊鼻咽癌患者,均行调强放射治疗,放射治疗前1周内和放射治疗50Gy时均行MRI及DWI检查,比较放疗前后MRI及DWI-MRI情况。结果 56例放疗后肿瘤病灶缩小,3例变化不明显,1例增大,与放疗前比较差异具有统计学意义(P<0.05)。放疗后弥散加权成像信号减低,表观弥散系数(apparentdiffusion coefficient,ADC)值增大,与放疗前比较差异具有统计学意义(P<0.05)。52例颈部转移性淋巴结缩小。结论 MRI扩散加权成像可快速,灵敏显示鼻咽癌放疗前后的变化,对IMRT的疗效评价具有很好的临床应用价值。
Objective To evaluate the role of DWI-MR imaging in intensity modulated radiotherapy （IMRT） for nasopharyngeal carcinoma （NPC）. Methods We retrospectively analyzed the MR characteristics of 60 NPC patients treated by IMRT. MRI was carried out at pre-radiotherapy and during IMRT at accumulative dose of 50 Gy, and compared the MRI, DWI-MRI of the lesions before and after the treatment. Results After IMRT, 56 of the lesions decreased in size, 3 showed no obvious change, and 1 increased in size, with significant differences from pretreatment （ P 〈0.05） ; the signal intensity of diffusion weighted imaging （DWI） significantly decreased, while the apparent diffusion coefficient （ADC） remarkably increased as compared with pretreatment （ P 〈0.05）. Metastatic lymph nodes became smaller in 52 cases. Conclusion As a rapid and sensitive new MR technique, it can desirably manifest the changes in NPC after radiotherapy, and can be applied to the evaluation of the results of IMRT.
出处
《医学影像学杂志》
2012年第10期1635-1638,共4页
Journal of Medical Imaging
基金
江苏省自然科学基金资助(编号:BK2008479)
关键词
鼻咽癌
调强放疗
磁共振
Nasopharyngeal carcinoma
Intensity modulated radiation therapy
Magnetic resonance imaging
