摘要
药物是否安全和有效是药物研发成功与否的决定性因素。就药物研发的整个流程而言,毒性是终止药物研发的重要原因之一。药物毒理学研究贯穿于新药发现阶段、临床前安全性评价和上市后跟踪监督的全过程,因此药物的毒理学研究至关重要。简要综述了药物毒理学研究过程中所涉及的技术方法以及研究新动向,并主要介绍了组学技术的发展。
If the drug is safe and effective is the decisive factor to determine whether the drug development is successful or not.As far as the entire drug development process is concerned,toxicity is one important reason for the termination of drug development process.Studies on drug toxicology are throughout the entire process of drug discovery stage,preclinical safety evaluation,and after-sale track supervision,as a result the drug toxicology studies is critical.This article briefly summarized the technology,methods,and new research trends involved in drug toxicology studies,and introduced the development of omics technology.
出处
《药物评价研究》
CAS
2012年第4期241-245,共5页
Drug Evaluation Research
基金
"重大新药创制"科技重大专项"十二五"计划(2012ZX09505001-001)
关键词
毒理学
替代实验
组学技术
toxicology； replace experiment； omics technology
