摘要
目的 选取能够有效地延缓急性氧惊厥发生的中药 ,探讨其预防作用及其与 SOD活性的关系。方法 观察给药小鼠在高压氧条件下发生惊厥的潜伏期 ,用改良的邻苯三酚法测定惊厥发生后小鼠肺、脑组织中超氧化物歧化酶 ( SOD)活性。结果 阿魏酸、当归、三七、绞股蓝、丹参等中药均可明显延长氧惊厥发生的潜伏期 ( P<0 .0 1) ;多数实验组之间惊厥后肺、脑组织中 SOD活性没有明显差异 ( P>0 .0 5 )。结论 当归、三七、丹参等具有活血化瘀功效的中药对于急性氧惊厥的发生有较好的预防作用。单用
Objective To select the Chinese traditional drugs which could prevent acute oxygen toxicity and to inquire the relationship between their prophylactic effect and SOD activity.Methods Convulsion latencies of mice under hyperbaric oxygen were observed and SOD activity were measured by improved pyrogallic acid method.Results Some Chinese traditional drugs such as Radix Angelicae Sinensis,Radix Notoginseng,Herba Gynostemmatis,Radix Salviae Miltiorrhizae and Ferulic acid could prolong convulsion latency significantly.There were no significant differences in SOD activity of lung and brain among most experimental groups after the convulsion.Conclusions Chinese traditional drugs with blood circulation invigorating efficacies such as Radix Angelicae Sinensis,Radix Notoginseng and Radix Salviae Miltiorrhizae have positive prophylactic effect on acute oxygen toxicity.But the SOD activity alone could not reflect clearly the mechanism through which these drugs had prevented acute oxygen toxicity by eliminating oxygen free radicals.
基金
军队九五科研项目!(96M075)
关键词
中药
氧惊厥
预防
超氧化物歧化酶
当归
Chinese traditional drug Oxygen convulsion-prophylaxis SOD
