摘要
目的:探讨新序贯疗法治疗消化性溃疡幽门螺杆菌(Hp)感染的临床疗效。方法:将2010年6月-2011年6月笔者所在医院收治的80例消化性溃疡幽门螺杆菌感染患者随机分为两组,每组各40例,对照组给予标准三联疗法:雷贝拉唑10mg+阿莫西林1000mg+克拉霉素500mg,2次/d,疗程为7d。治疗组应用新序贯疗法:前5d应用雷贝拉唑10mg+阿莫西林1000mg,2次/d;后5d雷贝拉唑10mg+克拉霉素500mg+替硝唑500mg,2次/d。比较两组的疗效。结果:两种治疗方法对消化性溃疡幽门螺杆菌感染均有较高的根除率,但治疗组Hp根除率显著优于对照组,差异有统计学意义(P<0.05)。结论:新序贯疗法治疗幽门螺杆菌根除率高、不良反应少、依从性好,值得临床广泛推广和应用。
Objective ：To investigate the clinical efficacy of a new sequential therapy in the treatment of peptic ulcer helicobacter pylori.Methods ：80 patients with peptic ulcer patients with helicobacter pylori infection from Jun 2010 to Jun 2011 in our hospital were randomly divided into two groups, each of 40 cases, the control group received standard triple therapy ： rabeprazole 10 rag, amoxicillin 1000 mg and clarithromycin 500 mg, l^id, treatment for 7 days. Treatment group, sequential regimen ： 5 d before application of rabeprazole 10 rag, amoxicillin 1000 mg, bid ; After 5 d rabeprazole 10 mg, clarithromycin 500 mg and tinidazole 500rag, bid.Results ：The two groups of treatment of peptic ulcer helieobacter pylori infection had a high eradication rate, but the treatment group Hp eradication rate was significantly higher, the difference was statistically significant（P〈0.05）.Conclusion ： Sequential regimen in Hp eradication rate, fewer adverse reactions, good compliance, and is worthy of extensive promotion and application.
出处
《中外医学研究》
2012年第29期6-7,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
序贯疗法
消化性溃疡
幽门螺杆菌
Sequential regimen
Peptic ulce
Helicobacter pylori
