摘要
目的比较轻度认知功能损害（mild cognitive impairment，MCI）患者与正常老年人睡眠质量的差异，并分析睡眠与认知功能之间可能的关系。方法采取随机整群抽样方法，对320例MCI患者（MCI组）和相匹配的630名健康老年人（对照组）使用匹兹堡睡眠质量指数量表（Pittsburgh Sleep Quality Index，PSQI）评估睡眠情况，使用简易精神状态检查量表（Mini—Mental State Examination，MMSE）和蒙特利尔认知评定量表（Montreal Cognitive Assessment，MoCA）进行认知功能的检测。结果MCI组有睡眠障碍者110例，占34．3％，对照组有睡眠障碍者170名，占27．0％，2组比较差异有统计学意义（X^2=7．35，P〈0．01）；MCI组与对照组PSQI总分[（6．11±4．29）分：（5．46±3．94）分]、睡眠时间因子Ⅲ[（0．98±0．98）分：（1．14±1．06）分]、睡眠效率因子Ⅳ[（0．81±1．06）分：（1．044±1．18）分]比较差异有统计学意义（F=4．21，P=0．04；F=6．90，P=0．00；F=7．51，P=0．00），MMSE评分和MoCA评分均与PSQI总分呈负相关（r=-0．09，P=0．00；r=-0．12，P=0．00）。结论MCI患者存在睡眠障碍，其认知功能减退与睡眠质量下降存在一定的关系。
Objective To assess the sleep quality in the aged with mild cognitive impairment （MCI）. Methods Altogether 320 MCI elderly and 630 elderly without MCI were assessed the quality of sleeping with the Pittsburgh Sleep Quality Index （PSQI）, and cognitive functioning with the Montreal Cognitive Assessment （MoCA） and Mini-Mental State Examination （ MMSE）. Results There were 34. 3 percent of MCI elderly and 27.0 percent of controls had sleep problems, and the difference between the two groups was significant（X^2 =7. 35,P 〈0. 01 ）. The mild correlations between the scores of MoCA and PSQI （r = -0. 12,P =0.00）, MMSE and PSQI（r = -0. 09 ,P =0. 00） were significant. Conclusions The aged with MCI have lower sleep quality than ones with normal cognition, which may be correlated with their cognitive impairments.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2012年第5期295-298,共4页
Chinese Journal of Psychiatry
基金
河北省科技支撑计划重大项目（09276103D）
