摘要
目的探讨CC族趋化因子受体7(CCR7)和CXC族趋化因子受体4(CXCR4)在肺癌组织中的表达及临床意义。方法采用免疫组织化学检测72例肺癌组织标本和30例良性肺疾病肺组织标本中CXCR4和CCR7的表达情况,并分析其不同临床病理特征中表达的差异。结果 CCR7和CXCR4在肺癌组织中的表达阳性率均明显高于正常肺组织,差异有统计学意义(P<0.01);CCR7和CXCR4表达与肺癌患者的TNM分期,纵膈淋巴结转移密切相关(P<0.01),与年龄、性别、病例组织学类型等均无关(P>0.05),并且Spearman相关分析显示,CXCR4表达与CCR7表达呈高度正相关(r=0.623,P<0.001)。结论 CXCR4和CCR7在肺癌纵膈淋巴转移中发挥重要作用。
Objective To explore the expression of the CC chemokine receptor-7 （CCR7） and CXC chemokine receptor-4 （CXCR4） in lung cancer and its significance. Methods By using immunohistoehemistry technique ,the expression of CXCR4 and CCR7 in the cancer specimens of 72 patients with lung cancer and 30 samples of lung tissue from benign pulmonary disease were detected, and analyzed its different clinical and pathological features of expression differences. Results The express positive rate of CCR7 and CXCR4 in the observation group were significantly higher than that in the control group, the difference was statistically significant （P 〈 0.01 ） ;The expression of CCR7 and CXCR4 was closely related to the TNM stages of lung cancer and local infiltra- tion depth;lymph node metastasis （P 〈 0.01 ）, but not to the age, gender and histological type （P 〉 0.05 ）. The Spearman rank corre- lation showed that CXCR4 expression and CCR7 expression were highly correlated （ r = 0. 623, P 〈 0.001 ）. Conclusion The abnor- mal expression of CXCR4 and CCR7 play an important role in the diaphragmatic metastases of lung cancer
出处
《中华全科医学》
2012年第11期1713-1715,共3页
Chinese Journal of General Practice
