摘要
目的观察苯扎氯铵与碘伏治疗肢体大面积皮肤缺损并感染的效果。方法将我院收治的56例肢体大面积皮肤缺损并感染患者随机分为两组,在清创手术及皮瓣转移术或皮肤移植术后分别采用苯扎氯铵与碘伏冲洗治疗,观察两种消毒剂的疗效、并发症、肉芽生长速度、皮肤爬行速度及内固定材料对创面的影响。结果苯扎氯铵组总有效率96.43%,碘伏组总有效率为85.71%,苯扎氯铵组的肉芽生长速度、皮肤爬行速度、内固定材料对创面的影响、并发症发生率方面均明显优于碘伏组,上述指标组间差异均具有统计学意义(P值均<0.05)。结论苯扎氯铵能加速创面的愈合,有较强的杀菌、控制局部感染作用,且对皮肤无刺激性,临床效果优于碘伏,是临床消毒抑菌的首选治疗药物。
Objective To observe the effect of benzalkonium chloride and povidone-iodine in the treatment of patients with large area of skin defect and infection in limbs. Methods Total 56 cases with large area of skin defects and infection in limbs in our hospital from September 2008 to November 2010 were randomly divided into two groups. After the debridement surgery and skin flap or skin graft surgery, benzalkonium chloride and povidone-iodine irrigation treatment were performed, the efficacy of two disin- fectants and local adverse reactions were observed. Results The total effective rate was 96.43% in the benzalkouium chloride group and 85.71% in the povidone-iodine group. The growth of granulation, elongation of skin, effect of internal fixation materials on wound and the incidence of complication in the benzalkonium chloride group were better as compared to the povidone-iodine group. There was statistically significance, P 〈 0.05. Conclusion The benzalkonium chloride can accelerate wound healing, it has a strong bactericidal control on the local infection, and has non-irritating to the skin. It is the first choice for the treatment of antibacterial drugs for clinical disinfection.
出处
《中华全科医学》
2012年第11期1679-1680,共2页
Chinese Journal of General Practice
关键词
苯扎氯铵
碘伏
皮肤缺损
感染
创面修复
Benzalkonium chloride
Iodophor
Skin defects
Infection
Wound repair
