摘要
目的:检测parafibromin蛋白在人颌骨骨肉瘤(osteosarcoma of the jaws,JOS)中的表达情况,探讨其在JOS的发生、发展中的作用。方法:采用免疫组织化学的方法检测parafibromin蛋白在47例JOS和11例颌骨骨化纤维瘤(ossifying fibroma of the jaws,JOF)中的表达情况。结果:JOS中,parafibromin高表达、中等表达、低表达患者分别占48.9%(23/47)、40.4%(19/47)和10.7%(5/47);JOF中,三者所占的百分率分别为90.9%(10/11)、9.1%(1/11)和0.0%(0),与JOS相比,差异有统计学意义(U=147.5,P=0.012);parafibromin在高分化型JOS中的表达水平高于传统型JOS(U=71.0,P=0.021);parafibromin的表达情况与临床病理参数间无相关性(P>0.05)。结论:parafibromin蛋白在JOS中表达下调,这种表达的减少可能与JOS的分化和恶性程度有关。
Objective： To investigate the expression of parafibromin in osteosarcoma of the jaws（JOS） and to explore its effects on tumorigenesis and progression.Methods： The expression of parafibromin was studied in 47 JOS and 11 ossifying fibroma of the jaws（JOF） by immunohistochemically staining.Results： In JOS,the high,medium and low levels of parafibromin expression were detected in 48.9%（23/47）,40.4%（19/47）,and 10.7%（5/47） of the cases,respectively;correspondingly,the different expressions were seen in 90.9%（10/11）,9.1%（1/11）,and 0.0%（0） JOF cases respectively.The difference between JOS and JOF groups was significantly different（U=147.5,P=0.012）.In highly differentiated JOS,the expression of parafibromin was significantly higher than that in the conventional JOS（U=71.0,P=0.021） but there were no statistically correlations between the expression of para-fibromin and clinical-pathological parameters of JOS（P0.05）.Conclusion： It is possible that the down-regulation of parafibromin may be associated with the differentiation and malignant degree of JOS.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2012年第5期792-796,共5页
Journal of Peking University:Health Sciences
基金
国家自然科学基金(81030018
81141092)资助~~
