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肺部给药疫苗装置的研究进展(英文) 被引量：3

Recent development in aerosol devices for pulmonary vaccine delivery
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摘要 讨论了可用于肺部给药疫苗的装置,描述了采用气溶胶进行肺部给药激发免疫的可能性。从疫苗的稳定性和抗原性来看,气溶胶装置为免疫接种提供了另外一个可行的途径。同时,肺部给药作为疫苗接种的一种途径,其非侵入性以及其相对的安全性和低成本特性也给公共卫生提供了光明的前景。 This review will discuss aerosol device technologies available for pulmonary vaccine deliveries.The possibilities of adopting aerosol-generation for the purpose of pulmonary immunization are described.Aerosol-generation systems might offer advantages in respect to vaccine stability and antigenicity.The noninvasive,relatively safe and low-cost net of pulmonary delivery may provide great benefits to the public health vaccination campaign.
作者 吕冬梅
机构地区 Office of Generic Drugs
出处 《北京大学学报（医学版）》 CAS CSCD 北大核心 2012年第5期683-687,共5页 Journal of Peking University:Health Sciences
关键词 气雾剂 疫苗 雾化器和汽化器 粉剂 吸入 Aerosols Vaccines Nebulizers and vaporizers Powder Inhalation
分类号 R944.7 [医药卫生—药剂学]
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参考文献40

  • 1Woodland DL, Randall TD. Anatomical features of anti-viral im- munity in the respiratory tract [J]. Semin Immunol, 2004, 16 (3) : 163 -170.
  • 2Brandtzaeg P. Humoral immune-response patterns of human muco- sac: induction and relation to bacterial respiratory tract infections [J]. J Infect Dis, 1992, 165(Suppl 1) : S167 -S176.
  • 3Breiman RF, Butler JC, McInnes PM. Vaccines to prevent respir- atory infection: opportunities on the near and far horizon [ J ]. Curr Opin Infect Dis, 1999, 12(2) : 245 -152.
  • 4Poulter LW. Pulmonary macrophages [M]//Stockley RA. Pulmonary Defences. Chichester, UK: John Wiley & Sons Ltd, 1997:77 -92.
  • 5Banchereau J, Briere F, Caux C, et al. Immunobiology of dendri- tic cells [ J]. Annu Rev Immunol, 2000, 18: 767- 811.
  • 6Bienenstock J, McDermott MR. Bronchus- and nasal-associated lymphoid tissues [ J]. Immunol Rev, 2005, 206: 22- 31.
  • 7Mayer L, Walker WA. Development and physiology of mucosal de- fense: An introduction[M]//Mestecky J, Lamm ME, Strober W, et al. Mucosal immunology. CA, USA: Academic Press, 2005:1 -5.
  • 8Gupta PK, Hickey AJ. Contemporary approaches in aerosolized drug delivery to the lung [J]. J Control Release, 1991, 17(2) : 129 - 148.
  • 9Reynolds HY. Modulating airway defenses against microbes [ J ]. Carr Opin Pulm Med, 2002, 8(3) : 154 -265.
  • 10Leung K, Louca E, Coates AL. Comparison of breath-enhanced to breath-actuated nebulizers for rate, consistency, and efficiency [J]. Chest, 2004, 126(5): 1629-1627.

同被引文献41

  • 1Jasmine Tomar,Wouter FTonnis,Harshad P.Patil,Anne H.de boer,Paul Hagedoorn,Rita Vanbever,Henderik W.Frijlink,Wouter L.J.Hinrichs.Pulmonary immunization:deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination[J].Acta Pharmaceutica Sinica B,2019,9(6):1231-1240. 被引量：3
  • 2陈桂良,侯惠民.吸入用气雾剂雾粒测定方法的评价[J].中国医药工业杂志,2007,38(3):194-199. 被引量：24
  • 3赵先铭,李万猛,唐顺发.威支灵喷雾免疫的应用报告[J].中国家禽,2007,29(7):46-47. 被引量：1
  • 4Hanghney J,Price D,Barnes NC,et al.Choosing inhaler devicesfor people with asthma:current knowledge and outstandingresearch needs [j].Respir Med,2010,104:1237-1245.
  • 5Dolovich MB,Dhand R.Aerosol drug delivery:developments indevice design and clinical use [j].Lancets 2011,377(9770):1032-1045.
  • 6SancKis J,Corrigan C,Levy ML,et al.Inhaler devices-From theoryto practice [ j].Respir Med,2013,107(4):495-502.
  • 7Xu LM,Zhang QX,Zhou Y,et al.Engineering drug ultraiine parti-cles of beclomethasone dipropionate for dry powder inhalation [j ].Int J Pharm,2012,436(1/2):1-9.
  • 8The United States Pharmacopeial Convention.US Pharmacopeia/-Nationai Formulary [M].Baltimore:United Book Press,2011:231-239.
  • 9Council of Europe.European Pharmacopeia 7.0.[M].Strasbourg:the Directorate for the Quality of Medicine & HealthCare of theCouncil of Europe,2011:274-285.
  • 10Pilcer G,Vanderbist F,Amighi K.et al.Correlations betweencasc-ade impactor analysis and laser diffraction techniques for thedetermination of the particle size of aerosolized powderformulations [ J].Int J Pharm.2008,358(1/2):75-81.

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北京大学学报（医学版）
2012年 第5期

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