摘要
目的观察锝[99Tc]亚甲基二膦酸盐注射液对活动期类风湿性关节炎的临床疗效及实验室指标的变化。方法将78例RA患者随机分为观察组(38例)和对照组(40例),观察组采用锝[99Tc]亚甲基二膦酸盐注射液联合甲氨蝶呤、强的松、来氟米特治疗,对照组采用单纯口服甲氨蝶呤、强的松、来氟米特治疗,疗程为90d,比较两组患者治疗后临床疗效及实验室指标的变化,并记录不良反应。结果观察组总有效率为94.7%,对照组总有效率为70.0%,两组患者临床疗效及实验室指标较治疗前均有改善,两组总有效率比较差异有统计学意义(P<0.05);与对照组比较,经90d治疗后观察组关节肿胀数、关节压痛数、晨僵时间、医生评价、病人评价、握力、CRP、ESR均明显改善,差异有统计学意义(P<0.05或P<0.01),两组间类风湿因子的改善值差异无统计学意义(P>0.05)。两组均无严重不良反应发生,其不良反应发生率比较差异无统计学意义(P>0.05)。结论锝[99Tc]亚甲基二膦酸盐注射液联合甲氨蝶呤、强的松、来氟米特可明显改善活动期类风湿性关节炎的临床疗效及实验室指标,其安全性高,不良反应发生率低。
Objective To observe the clinical effect and laboratory indexes of 99 Tc-MDP on active rheumatoid arthritis.Methods 78 patients with rheumatoid arthritis were randomly divided into two groups （observation group and control group）.38 patients in the observation group were given 99 Tc-MDP combined with MTX,prednisone and LEF,and 40 patients in the control group were given oral drugs only.After 90 days of treatment,the clinical effect and laboratory indexes were evaluated and adverse effect was also noted.Results The total effectual rate of observation group was 94.7%,while that of control group was 70.0%.The clinical effect and laboratory indexes of all patients received therapy were improved.There were statistically difference between the total effectual rates of the two groups （P 0.05）.Index of joint tenderness,swelling,morning stiffness,physician assessment,patient assessment,strength,CRP and ESR of observation group （P 0.05 or P 0.01） except RF（P 0.05）were all improved significantly comparing with control group after 90 days of treatment.There was no significant difference in adverse effect of both groups（P 0.05）.Conclusion Therapy of 99 Tc-MDP combined with MTX,prednisone and LEF is effective and safe in treatment of rheumatoid arthritis.
出处
《中国医药科学》
2012年第20期41-42,44,共3页
China Medicine And Pharmacy
