摘要
目的探讨尿肾损伤分子1(KIM-1)在心肺转流(CPB)后急性肾损伤(AKI)早期诊断价值。方法检测140例患者CPB术后2、6、12、24和48h血清肌酐(SCr)、尿肌酐(UCr)和尿KIM-1水平。结果尿KIM-1/UCr在术后2h即明显升高,曲线下面积为0.889。当尿KIM-1/UCr比率为2.0ng/mg作为诊断界点时,诊断的敏感性和特异性分别82.6%和87.0%;当术后6h尿KIM-1/UCr比率为5.5ng/mg作为诊断界点时,预测AKI进展的敏感性和特异性分别为81.6%和81.8%。结论尿KIM-1/UCr比率可作为CPB术后AKI早期诊断及预测进展的良好指标。
Objective To evaluate the diagnostic value of kidney injury molecule I（KIM-1） in the early diagnosis of acute kidney injury（AKI） after cardiopulmonary bypass（CPB）. Methods The levels of urine KIM-1 ,urinary creatinine（UCr） and serum creatinine（SCr） were measured at different time points in 140 patients undergoing CPB. Reusults The urine KIM-1 and UCr were increased with AUC of 0. 889 at 2 h after CPB. Taking the ratio of urine KIM-1 to UCr 2.0 ng/mg as a cutoff value, the sensitivity and specificity in diagnosing AKI were 82.6% and 87.0%, respectively. Taking the ratio of urine KIM-1 to UCr 5.5 ng/mg as a diagnostic cutoff value at 6 h after operation, the sensitivity and specificity for predicting AKI were 81.6%和 81.8%, respectively. Conclusion The ratio of urine KIM-1 to UCr after cardiac surgery under CPB is a powerful biomarker for early diagnosing AKI and predicting the prognosis of AKI.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第19期2280-2282,共3页
Jiangsu Medical Journal
关键词
肾损伤分子1
急性肾损伤
心肺转流
Kidney injury molecule-1
Acute kidney injury
Cardiopulmonary bypass
