摘要
本文报告13例原发肾上腺皮质功能减退(PAF)患者,31例继发肾上腺皮质功能减退(SAF)患者及42例正常人血浆ACTH及血清皮质醇测定的结果。血浆ACTH:PAF组显著高于正常组,SAF组显著低于正常组。PAF组与SAF组或正常组无重叠,但SAF组与正常组有较多重叠(83.9％)。血清皮质醇:PAF组、SAF组均显著低于正常组;PAF和SAF两组相似,与正常组有少量重叠(13.6％)。其中14例SAF、3例PAF和13例正常人做了氨基导眠能(AG)试验。SAF和正常人两组服AG后血浆ACTH的重叠现消失。本文结果表明:血清皮质醇是诊断肾上腺皮质功能减退的直接证据,但不能鉴别PAF和SAF,而血浆ACTH可以鉴别两者;氨基导眠能试验有助于鉴别SAF和正常人。
The levels of plasma ACTH and serum cortisol were determined in 13 patients with primary adrenal failure (PAF), 31 patients with secondary adrenal failure (SAF) and 42 normal people. The levels of plasma ACTH were significantly higher in patients with PAF and apparently lower in patients with SAF than those in the normal people. No overlaping was found in the ACTH level between the patients with PAF and the normal people but an overlaping rate of 83.9% in the ACTH level between the patients with SAF and the normal people was noticed. The level of serum cortisol were significantly decreased in the patients with PAF or SAF as compaired with those in the normal people and showed a few overlaping (13.6%) between the patients with PAF or SAF and the normal people. An aminoglutethemide (AG) test was done in 14 patients with SAF, 3 patients with PAF and 13 normal people. The overlaping of plasma ACTH between the patients with SAF and the normal people diappeared following the AG administrations. Our study suggests that (1) serum cortisol is useful in the establishment of adrenal failure but could not make a clear distinction between PAF and SAF; and (2) plasma ACTH could differentiate PAF from SAF; and (3) AG test could differentiate SAF from normal conditions.
出处
《军医进修学院学报》
CAS
1990年第3期246-249,共4页
Academic Journal of Pla Postgraduate Medical School
关键词
肾上腺机能减退
ACTH
诊断
放射免疫测定
Adrenal gland hypofunction Corticotropin Adrenal cortex hormones Radioimmunoassay
