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SUMO化修饰在DNA损伤响应中的作用 被引量：2

DNA Damage Response and SUMO Modification
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摘要 物理或化学等多种因素均可以引起DNA损伤。为维持机体基因组的稳定性,机体形成了精确完整的机制来修复损伤的DNA。SUMO(small ubiquitin-related modifier,SUMO)化修饰与其他蛋白翻译后修饰一样,具有多种生物学功能。近年来的研究表明,其在DNA损伤修复中也具有非常重要的作用。该文就DNA损伤修复、SUMO化修饰系统及其二者关系的最新研究进展作了较为全面的介绍和总结。 DNA damage can be produced widely in our body by physical and/or chemical factors. There fore, in order to maintain the genomic integrity, DNA must be protected from DNA damage and repaired correctly by forming accurate mechanism if DNA damage happened. SUMOylation has multiple biological functions like other post-translation modification. Emerging evidence has showed that SUMOs play vital roles in DNA damage repair. This review focuses on the newly research about DNA damage, SUMOylation and the relationship between them and provides a complete introducing and summarization.
作者 蒋华东 李钰
机构地区 哈尔滨工业大学生命科学与技术学院
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2012年第10期1049-1054,共6页 Chinese Journal of Cell Biology
基金 国家自然科学基金(No.31171252)资助项目~~
关键词 DNA修复 DNA损伤响应 SUMO化修饰 DNA repair DNA damage response SUMOylation
分类号 Q75 [生物学—分子生物学]
  • 相关文献

参考文献29

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二级参考文献22

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共引文献1

同被引文献55

  • 1庄严,王丹丹,柳忠兰,王建华,曹亦宾.吸烟对大鼠局灶性脑缺血后Caspase-3表达及细胞凋亡的影响[J].中国老年学杂志,2014,34(1):156-158. 被引量：3
  • 2陆嵘,房静远.表观遗传修饰与肿瘤[J].生命科学,2006,18(1):10-14. 被引量：29
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二级引证文献8

中国细胞生物学学报
2012年 第10期

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