摘要
对272例各种疾病患者及81例正常人以ELISA方法测定了ACA水平。结果表明,活动期SLE、RF阳性的RA、SS、PSS以及各种感染性疾病患者血清IgG-ACA阳性率分别为66％、38％、100％、50％及44%;IgM-ACA阳性率分别为53％、46％、20％、50％及42％。而非活动期SLE、RF阴性的RA及其它疾病患者的ACA均值及阳性率与正常人无显著差异,提示ACA与SLE等疾病病情的严重性及活动性有关,并可作为提示感染及监督疗效的一个参考指标。
The determination of serum anti-cardiolipin antibodies (ACA) by ELISA among 272 patients with various diseases and 81 normal controls was reported and its clinical significance was evaluated. The results showed that the positive rates of ACA in active SLE, RF positive RA, SS, PSS and infectious diseases groups were 66%, 38%, 100%, 50% and 44%for IgG; and 53%, 46%, 20%, 50% and 42% for IgG respectively. In contrast, the positive rates of both IgG and IgM-ACA in inactive SLE, RF negative arthritis and othor disease control groups were much lower, without significant differences from normal controls. ACAS positivity were related with the severity and activity of the disease in patients with SLE, RA, SS, and PSS. The thrombocytopenia in SLE, the extraarticular manifestions in RA, the articular and cutaneous lesions of Lyme disease were showed to be closely related with the high levels of ACA. The results also suggested that ACAs couid be used as a diagnostic tool for some infectious diseases and as a guide in therapy.
出处
《军医进修学院学报》
CAS
1990年第1期66-69,共4页
Academic Journal of Pla Postgraduate Medical School
关键词
抗心磷脂抗体
自身免疫病
红斑狼疮
ELISA
Anti-cardiolipin anlibody Enzyme-linked immunosorbent assay Autoimmune diseases Infection Lupus erythematosus
systemic
