摘要
目的:制备盐酸左氧氟沙星耳用温敏凝胶,并考察其在耳道内的滞留效果。方法:冷法制备盐酸左氧氟沙星耳用温敏凝胶,均匀设计法拟合回归方程,优化P407和P188浓度比例,采用耳道内窥镜和核磁共振成像分别从直观视觉和影像学角度考察其在兔耳道的形态与滞留时间。结果:回归方程为:y=95.6-307x(1)+141x(2),其中x(1)、x(2)分别是P407和P188浓度,选取浓度P407/P188=24%/5%制成盐酸左氧氟沙星温敏凝胶;耳道内窥镜与核磁共振表明本凝胶在兔耳道内迅速发生了相转变,粘附于耳道内,滞留时间超过8 h。结论:制备的盐酸左氧氟沙星耳用温敏凝胶能延长药物在耳道内的滞留时间,达到缓释效果,减少用药次数。
OBJECTIVE To prepare the levofloxacin hydrochloride ear thermosensitive gels and investigate the stagnation in the ear canal.METHODS The levofloxacin hydrochloride ear thermosensitive gels were prepared by cold method.The regression equation was established and the concentration of P407 and P188 were optimized by uniform design.The stagnation of the thermosensitive gels in the rabbit ears were investigated by ear endoscope and Magnetic Resonance Imaging（MRI） respectively.RESULTS The regression equation was y=95.6-307x（1）＋141x（2）.The optimized concentration of P407/P188 was 24%/5%.It was proved that the levofloxacin hydrochloride ear thermosensitive gels turned into gelation quickly and stayed in the ear over 8 hours.CONCLUSION The levofloxacin hydrochloride ear thermosensitive gels improve the stagnation in ears,slow the release of the drug and reduce the times of usage.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第19期1520-1522,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸左氧氟沙星
温敏凝胶
泊洛沙姆
滞留性
levofloxacin hydrochloride
thermosensitive gels
poloxamer
stagnation
