摘要
阿尔茨海默病（AD）是最常见的痴呆类型，并随着人口老龄化将会变得越来越普遍。在AD出现临床症状前数十年脑内就可发生病理改变，临床诊断标准不能准确诊检轻度AD及无症状AD。AD的早期诊断越来越受到重视，对发生在AD早期的不可逆性神经损伤前的干预治疗尤为重要。神经影像标志物是最有发展前途的诊断早期AD的方法，PET功能性神经影像是一种能够在早期进行AD病理及分子生物学检查的极具灵敏度、特异度、无创性、客观和定量的方法，因此能够诊断出早期的、轻微且无临床症状的老年痴呆症。
Alzheimer disease（AD） is the most common type of dementia and will become increasingly prevalent with population aging. It is accepted that the pathologic changes underlying AD appear in the brain years to decades before the symptomatic stages. Clinical measures of cognitive impairment, as used for defi- nition of dementia, will not allow early diagnosis of AD-pathology in the mild or asymptomatic stages. There has been growing interest in early diagnosis of this disease, particularly regarding the initiation of new treat- ment strategies ahead of the onset of irreversible neuronal damage. Brain imaging markers are among the most promising candidates for this diagnostic challenge. PET has been demonstrated to be a most sensitive, specific, noninvasive, objective and quantitative method for early identification of AD-pathology and molecu- lar biology, thus for prediction of dementia of the Alzheimer type, even in the mild and asymptomatic stages.
出处
《国际放射医学核医学杂志》
2012年第5期257-263,共7页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（81271516）
