摘要
以硝酸胍和丙二酸二乙酯为起始原料 ,经环合、氯化、水解、甲氧基化 ,合成了 2 -氨基 - 4-氯 - 6 -甲氧基嘧啶 .其收率达到 70 % ,其结构经 IR测试确定 .目标化合物 2 -氨基 - 4-氯 - 6
Guanidine nitrate and diethyl malonate are used to synthesis 2 amino 4 chloro 6 methoxypyrimidine,by cyclization, chloridization hydrolysis and methoxylation. The yield reaches 70% and the structure is confirmed by IR test. The goal compound, 2 amino 4 chloro 6 methoxypyrimidine, is a key intermediate for preparing anticancer medicine.
出处
《郑州大学学报（自然科学版）》
CAS
2000年第2期87-88,共2页
Journal of Zhengzhou University (Natural Science)
