摘要
目的探讨半乳糖凝集素-3(Gal-3)、透明质酸(HA)与胆道闭锁(BA)患儿术后肝损害、肝纤维化的关系。方法选择行Kasai术术后BA患儿为BA组(n=35),同期体检健康儿童为健康对照组(n=10)。BA组根据胆红素水平分为黄疸组(n=11)和无黄疸组(n=24),根据胃镜下食管静脉曲张情况分为门静脉高压(PH)组(n=27)和非PH组(n=8)。应用自动生化仪检测2组肝功能,采用ELISA检测2组血清Gal-3水平,采用放射免疫法检测2组血清HA水平。结果 BA组肝损害、肝纤维化程度较健康对照组重,血清Gal-3、HA水平均较健康对照组显著升高(Pa<0.05);黄疸组肝损害、肝纤维化程度较无黄疸组重,血清Gal-3、HA水平均较无黄疸组显著升高(Pa<0.05);无黄疸组血清Gal-3水平较健康对照组显著升高(P<0.05);PH组血清Gal-3水平较非PH组显著升高(P<0.05);血清Gal-3水平与总胆红素、ALT、γ-谷氨酸转肽酶水平呈正相关(Pa<0.05),与HA水平亦呈正相关(P<0.05)。结论血清Gal-3水平与BA术后患儿肝损害程度和肝纤维化程度密切相关,可作为BA术后判断患儿预后的重要生化指标。
Objective To investigate the serum galeetin- 3 （Gal -3 ）, hyaluronic acid （HA） levels in postoperative biliary atresia（BA） patients and the relation of these levels with liver dysfunction ,liver fibrosis. Methods The children after Kasai surgery as the BA group（ n 35 ）, normal physical examination of children as the healthy control group（ n = 10）. BA group were divided into jaundice group （n = 11 ） and non -jaundice group （n = 24 ） according to the level of bilirubin, and were divided into portal hypertensionl（PH） group （n = 27 ） and non PH group （n = 8 ） according to the esophageal varices. All children＇s liver function was measured by automatic biochemical analyzer, and the ser- um level of Gal -3 was determined by ELISA ,while the level of HA was measured by radioimmunoassay. Results The degrees of liver dys- function and liver fibrosis were severer in BA group than those in healthy control group, the serum Gal - 3 and HA levels were higher than those of healthy control group（ P 〈 0. 05 ） ;The degrees of liver dysfunction and liver fibrosis of jaundice group were severer compared with non -jaundice group, and serum Gal -3 and HA levels were higher than those of non -jaundice group（Pa 〈 0.05 ） ;BA patients in jaundice group had considerably higher serum galectin - 3 level than those in non - jaundice group （ P 〈 0.05 ）. BA patients with portal hypertension had considerably higher serum Gal -3 level than those without portal hypertension （P 〈 0.05 ） ;There was close positive correlation between serum levels of Gal - 3 and total bilirubin, alanine aminotransferase, 7 - glutamyl transpeptidase （ Pa 〈 0. 05 ）, and close positive correlation between serum levels of Gal - 3 and HA （ P 〈 0. 05 ）. Conclusions Serum Gal - 3 level is closely associated with liver dysfunction and liver fibrosis in patients with postoperative BA. It is useful in monitoring the clinical outcome of patients with postoperative BA.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2012年第19期1530-1532,共3页
Journal of Applied Clinical Pediatrics
