摘要
目的分析上海市浦东新区原发性肝癌（PLC）患者发病和生存情况。方法以2002--2011年上海市浦东新区常住户籍居民为研究对象，计算PLC发病率及死亡率，按世界标准人口年龄构成标化后，分析不同性别、不同地区患者生存情况，同时探讨手术切除治疗对PLC预后的影响。结果2002--2011年上海市浦东新区PLC新发患者7981例，其中男性5754例，女性2227例，平均发病年龄分别为60．27岁和68．26岁。合计粗发病率为30．73／10万人年，其中男性粗发病率为44．30／10万人年，高于女性的17．16／10万人年，差异有统计学意义（u=3．46，P〈O．01）；男性标化发病率为25．72／10万人年，高于女性的8．22／10万人年，差异有统计学意义（u=3．00，P〈0．01）。PLC患者死亡7233例，其中男性5151例、女性2082例；合计粗死亡率为27．85／10万人年，其中男性为39．65／10万人年，高于女性的16．04／10万人年，差异有统计学意义（u=3．16，P〈O．01）；标化死亡率男性为22．77／10万人年，高于女性的7．39／10万人年，差异有统计学意义（u=2．80，P〈O．01）。男性在35岁、女性在45岁以后发病率和死亡率均明显升高。PLC患者1。5年生存率分别为19．88％、14．91％、12．19％、10．29％和8．56％。中心城区、城镇和农村地区患者总体生存时间的差异有统计学（x2=8．711，P=0．013）。手术切除组1～5年生存率均高于非手术组，差异均有统计学意义（u值分别为10．8、6．93、4．75、3．3、2．61，P值均〈0．01）。结论上海市浦东新区男性PLC发病率和死亡率较高，农村地区患者总体生存时间较低，手术治疗可改善其预后。
Objective To analyze the incidence and survival rates of primary liver cancer （PLC） among residents in Pudong district of Shanghai. Methods Permanent residents of Pudong district, Shanghai were recruited in the study between 2002 and 2011, among whom 7981 PLC cases were diagnosed and 7233 death cases were certified. Both morbidity and mortality of PLC were calculated and standardized （ASR） by the world population of 1966, in order to analyze the survival condition of PLC patients on gender or address, to explore the prognosis of surgical excision treatment. Results Among the incident cases of PLC between 2002 and 2011,5754 cases were males, with an average age of 60.27 ; while 2227 cases were females, with an average age of 68.26. The crude incidence rate for both sexes was 30.73 per 100 000 person-year, and was 44.30 per 100 000 person-year for males, higher than that in females, 17.16 per 100 000 person-year. The difference showed statistical significance （u=3.46, P〈0.01）. The ASR for incidence rates were 25.72 per 100 000 person-year in males and 8.22 per 100 000 person-year in females, respectively, with difference statistically significant （u= 3.00, P〈 0.01 ）. There were 7233 PLC death cases in total, including 5151 males and 2082 females, with the crude mortality rate as 27.85 per 100 000 person- year. Rate for males was 39.65 per 100 000 person-year, significantly different from 16.04 per 100 000 person-year in females, statistically （u=3.16, P〈0.01）. The ASRs for mortality were 22.77 per 100 000 person-year in males and 7.39 per 100 000 person-year in females, with statistically significant difference （u = 2.80, P〈 0.01 ）. Both incidence and mortality rates increased apparently for males aged over 35 and females aged over 45. The 1- to 5-year survival rates of PLC were 19.88%, 14.91%, 12.19%, 10.29% and 8.56%, respectively. There were statistically significant differences among urban, town and rural areas in the over-all survival rates （x2=8.711, P=0.013 ） ;The differences in 1- to 5-year survival rates between surgical and non-surgical groups showed statistically significant differences （u= 10.8,6.93,4.75,3.3 and 2.61, respectively, P^0.01 ）. Conclusion The incidence and mortality rates in males were significantly higher than in females and the over-all survival in rural area was significantly lower than in other areas of Pudong district, suggesting that surgical treatment could improve the prognosis of PLC.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2012年第10期1016-1020,共5页
Chinese Journal of Epidemiology
关键词
原发性肝癌
发病率
死亡率
生存率
Primary liver cancer
Incidence
Mortality
Survival rate
