摘要
目的回顾性分析白膜下睾丸实质剜除术与药物去势治疗Ⅳ期前列腺癌的疗效及副作用的差异。方法 2005年01月～2011年10月采用白膜下睾丸实质剜除术(n=70)和诺雷德联合康士得(n=62)治疗Ⅳ期前列腺癌并进行随访,分析其肿瘤缓解时间、总生存时间、手术并发症及对患者心理的影响。结果随访时间1～59个月,手术组和药物组肿瘤缓解时间分别为18个月和17个月,两组差异无显著性(χ2=0.166,P=0.682),总生存时间分别为33个月和31个月,两组差异无显著性(χ2=0.080,P=0.778)。手术组发生术后并发症的比率为10%,没有出现因睾丸切除导致的心理疾病。结论白膜下睾丸实质剜除术作为Ⅳ期前列腺癌白膜下睾丸实质剜除方法,具有疗效确切、对心理影响少及成本低的特点,可作为Ⅳ期激素依赖型前列腺癌去势治疗的首选方法。
【Objective】 To explore retrospectively the difference of therapeutic efficacy and side effect between subcapsular orchiectomy and medical castration in prostate cancer Patients-Ⅳ.【Methods】 In the retrospective study,132 consecutive Patients-Ⅳ were evaluated,the operation group（n =70） had primarily been treated by subcapsular bilateral orchiectomy and the medicine group（n =62） had received medical castration from Jan 2005～Oct 2011.Response to therapy,time of tumor remission,overall survival time,psychological disorders due to loss of organ and postoperative surgical complications were recorded.【Results】 The follow up time was 1～59 months.Median time of tumor remission of the operation group and medicine group were 18 and 17 months.The difference was statistically insignificant（χ2=0.166,P =0.682）.Median times of overall survival were 33 and 31 months respectively.The difference was statistically insignificant（χ2=0.080,P =0.778）.10% of the operation group showed minor postoperative complications.No psychological disease occurred following bilateral orchiectomy.【Conclusion】 Due to an effective and persistent oncological effectiveness,absence of psychological complications and cost-effective,bilateral subcapsular orchiectomy seems to be a practicable and advisable alternative in the first-line therapy of prostate cancer Patients-Ⅳ.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第24期52-55,共4页
China Journal of Modern Medicine
基金
广州市医药卫生科技项目(No:2012IA011159)
国家高新技术研究发展计划(863计划)子课题(No:2007AA022006)
