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甲氧明在髋关节置换术中的应用 被引量:1

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摘要 目的研究髋关节置换术中应用甲氧明防治椎管内麻醉所致低血压及术中骨水泥反应的可行性。方法选取2010年7一12月行髋关节置换术患者40例,采用随机数字表法分为甲氧明组(20例)和麻黄碱组(20例)。两组均行蛛网膜下隙与硬膜外联合阻滞,甲氧明组给予1mg甲氧明、麻黄碱组给予3mg麻黄碱静脉注射。放置骨水泥前,甲氧明组给予2mg甲氧明、麻黄碱组给予5mg麻黄碱静脉注射。观察两组患者麻醉前、麻醉后2、5、15min及放置骨水泥前、放置骨水泥后2、5、15rain心率、中心静脉压和有创动脉压变化。结果麻黄碱组麻醉后2min心率[(80.9±12.5)次/min]明显快于甲氧明组[(71.7±11.9)次/mini(P〈0.05);麻黄碱组麻醉后2、5min心率[(80.9±12.5)、(77.7±10.7)次/minl明显快于麻醉前[(69.4±10.61)次/minl(P〈0.01或〈0.05)。麻黄碱组放置骨水泥后2min心率[(82.9±9.6)次/rain]明显快于甲氧明组[(76.2±8.4)次/min](P〈0.05),且明显快于放置骨水泥前[(74.7±9.8)次/mini(P〈0.05)。两组患者麻醉前后及放置骨水泥前后均未出现低血压。两组术中失血量、总输入量及输血量比较差异无统计学意义(P〉0.05)。结论甲氧明和麻黄碱用于预防髋关节置换术中椎管内麻醉诱导所致低血压和术中骨水泥反应均有效,但甲氧明较少有心脏效应而更安全合适。
出处 《中国医师进修杂志》 2012年第29期73-75,共3页 Chinese Journal of Postgraduates of Medicine
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