期刊文献+

曲美他嗪对扩张型心肌病心力衰竭患者LVEF值的影响 被引量:8

暂未订购
导出
摘要 目的探讨曲美他嗪对扩张型心肌病心力衰竭患者LVEF值的影响。方法 24例扩张型心肌病心力衰竭患者,随机分为治疗组和对照组各12例。对照组采用常规治疗,治疗组在此基础上加用曲美他嗪,比较2组治疗前后LVEF值。结果服药4个月后,治疗组LVEF值由(34.1±5.2)%上升至(44.3±8.2)%,较治疗前明显升高(P<0.01),与对照组比较差异有统计学意义(P<0.05)。对照组LVEF值由(33.2±4.9)%上升至(37.4±7.1)%,与治疗前比较差异显著(P<0.01)。结论曲美他嗪治疗扩张型心肌病合并心力衰竭效果显著,可临床推广应用。
出处 《临床合理用药杂志》 2012年第29期48-49,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

同被引文献63

  • 1熊攀,周莉,刘芳.曲美他嗪治疗不稳定型心绞痛[J].中国实用医刊,2010,37(16):38-40. 被引量:6
  • 2Fragasso G, Palloshi A, Puccetti P, et al. A randomized clinical trial of trimetazidine, a partial free fatty acid oxi- dation inhibitor, in patients with heart failure [ J]. J Am Coil Cardiol, 2006,48 ( 5 ) :992-998.
  • 3deGoma E M, Vagelos R H, Fowler M B, et al. Emer- ging therapies for the management of decompensated heart failure: from bench to bedside [ J]. J Am Coil Cardiol, 2006,48 ( 12 ) : 2397-2409.
  • 4Tuunanen H, Engblom E, Naum A, et al. Trimetazi- dine, a metabolic modulator, has cardiac and extracardi- ac benefits in idiopathic dilated cardiomyopathy [ J ]. Cir- culation, 2008,118(12) :1250-1258.
  • 5Abbate A, Bussani R, Biondi Zoccai G G, et al. Persis- tent infarct-related artery occlusion is associated with an increased myocardial apoptosis at postmortem examination in humans late after an acute myocardial infarction [ J]. Circulation, 2002,106 ( 9 ) : 1051-1054.
  • 6Kantor P F, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mi- tochondrial long-chain 3-ketoacyl coenzyme A thiolase [ J ]. Circ Res, 2000,86 ( 5 ) : 580-588.
  • 7Lee L, Horowitz J, Frenneaux M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment [J]. Eur Heart J, 2004,25(8) :634-641.
  • 8Morin D, Elimadi A, Sapena R, et al. Evidence for the existence of [ 3H ]-trimetazidine binding sites involved in the regulation of the mitochondrial permeability transition pore[J]. Br J Pharmacol, 1998,123(7) :1385-1394.
  • 9Ferrari R, Pepi P, Ferrari F, et al. Metabolic derange- ment in ischemic heart disease and its therapeutic control [J]. Am J Cardiol, 1998,82(5A) :2K-13K.
  • 10Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardi- um to low-dose dobutamine in ischaemic cardiomyopathy [J]. Eur Heart J, 2001,22(23) :2164-2170.

引证文献8

二级引证文献87

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部