摘要
目的探讨香丹注射液致过敏性休克的临床特点及发生规律,为临床合理用药提供参考。方法检索1994年至2011年国内文献,收集香丹注射液致过敏性休克病例53例,应用药物流行病学方法对资料进行归纳分析。结果香丹注射液致过敏性休克多为速发型过敏性休克,发生在给药时间30 min内的占88.68%。过敏性休克以循环系统、呼吸系统、中枢神经系统症状多见,其中49例痊愈,4例死亡,死亡率7.55%。结论香丹注射液致过敏性休克的原因主要为患者体质、药物因素、临床合理用药3个方面。
Objective To investigate the clinical features and the occurrence regularity of anaphylactic shock induced by Xiangdan Injec- tion to provide reference for rational drug use. Methods The domestic literatures during 1994-2011 were retrieved. 53 cases of ana- phylactic shock caused by Xiangdan Injection were collected and the data were conducted the summary and analysis by the pharma- coepidmiology method. Results Most of the cases were the immediate type anaphylactic shock, which happened within 30 rain after ad- ministration accounted for 88.68%. The symptoms of circulatory,respiratory and center nervous systems in anaphylactie shock were more common. 49 cases were cured,and 4 cases died with the death rate of 7.55%. Conclusion The main reasons of anaphylactic shock caused by Xiangdan Injection are the patient＇s habitus,drug factors and clinical rational drug use.
出处
《中国药业》
CAS
2012年第20期75-76,共2页
China Pharmaceuticals
关键词
香丹注射液
过敏性休克
合理用药
Xiangdan Injection
anaphylactic shock
rational drug use
