摘要
FLJ10261(TEME16A)是新近发现的与胃肠道间质瘤(GISTs)关系密切的一个基因,由该基因编码的蛋白质DOG1,特异性表达于GISTs中,免疫组化及原位杂交证实,其阳性表达较KIT和PDGFRA更弥漫、更具有特异性,因此可能作为胃肠道间质瘤治疗的另一个靶点。笔者对DOG1与GISTs关系的研究进展进行综述。
FLJ10261 （TEME16A） is a recently defined gene that is closely related to gastrointestinal stromal tumors （GISTs）. The DOG1 protein encoded by this gene is specifically expressed in GISTs, and its positive expression is more extensive and specific than the expressions of KIT and PDGFRA as proved by immunohistochemistry and in situ hybridization. Thus, it may become an alternative therapeutic target for GISTs. This paper reviews the recent advances in the relationship between DOG1 and GISTs.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2012年第10期1287-1290,共4页
China Journal of General Surgery
