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抑癌基因CpG岛甲基化与结直肠癌关系的研究进展 被引量：3

CpG island methylation of tumor suppressor genes in colorectal cancer
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摘要 CpG岛甲基化可导致抑癌基因的表观遗传学转录失活,在某些情况下可能是抑癌基因失活的惟一机制,直接导致肿瘤的发生。笔者对Syk,p15,hMLHl,APC,DCC,p16等抑癌基因CpG岛甲基化与结直肠癌的关系进行简要综述,并提出存在的问题和展望。 CpG island methylation can lead to epigenetic transcription inactivation of the tumor suppressor gene, and in some circumstances it may be the only mechanism of tumor suppressor gene inactivation, which directly results in the occurrence of the tumors. This paper overviews the relations of the CpG island methylation of the tumor suppressor gene such as Syk, and ofpl5 with colorectal cancer, and also presents related problems and future considerations.
作者 彭星宇 曾庆黎
机构地区 江西省人民医院普通外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2012年第10期1279-1282,共4页 China Journal of General Surgery
基金 江西省科技厅资助项目(2010BSA14200)
关键词 结直肠肿瘤 抑癌基因 CPG岛 甲基化 综述文献 Colorectal Neoplasms Tumor Suppressor Gene CpG Islands Methylation Review
分类号 R735.3 [医药卫生—肿瘤]
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参考文献37

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二级参考文献56

共引文献32

同被引文献48

  • 1Xiao-UXu,JianYu,Hong-YuZhang,Meng-HongSun,JunGu,XiangDu,Da-RenShi,PengWang,Zhen-HuaYang,Jing-DeZhu.Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis[J].World Journal of Gastroenterology,2004,10(23):3441-3454. 被引量：43
  • 2杨祖立,汪建平,元云飞,蔡世荣,黄美近.结直肠癌侵袭性与脾酪氨酸激酶基因Syk启动子甲基化的关系[J].中华实验外科杂志,2005,22(1):68-70. 被引量：32
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引证文献3

二级引证文献9

中国普通外科杂志
2012年 第10期

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