摘要
目的对经皮冠状动脉介入治疗(PCI)术后不同抗血小板治疗方案疗效对比。方法将132例冠状动脉介入术后患者随机分入阿司匹林联合氯吡格雷双联组、阿司匹林氯吡格雷与西洛他唑三联组,双联组长期服用阿司匹林100 mg/d、氯吡格雷75 mg/d(12个月),三联组患者在双联用药基础上再加用西洛他唑100 mg/d(6个月),随访对比主要心脑血管事件发生率、血小板聚集率、药物不良反应发生情况。结果与双联组对比,三联组主要心脑血管事件(MACCE)发生明显降低,二磷酸腺苷(ADP)诱导的血小板聚集率与双联组差异有统计学意义(P<0.05),术后6个月三联组最小腔内径(MLD)和晚期管腔丢失与双联组比较差异有统计学意义(P<0.05),再狭窄率差异有高度统计学意义(P<0.01)。结论冠心病患者行PCI术后在阿司匹林联合氯吡格雷基础上加用西洛他唑,可进一步防止支架内血栓形成,晚期管腔丢失减少,再狭窄率降低。
Objective To investigate the efficacy of different antiplatelet therapy in patients after percutaneous coronary intervention（PCI）.Methods 132 patients with coronary heart disease were randomly assigned to double antiplatelet group and triple antiplatelet group after underwent PCI operation.The patients in double antiplatelet group were asked to take Aspirin 100 mg/d long term and Clopidogrel 75 mg/d for one year,while triple antiplatelet group took Cilostazol 100 mg/d for six month in addition.Follow-up was to investigate the difference of major adverse cardiac and cerebrovascular events（MACCE）,as well as platelet aggregation rate between the 2 groups.Results Compared to double antiplatelet group,MACCE of triple antiplatelet group decreased（P 0.05）.The difference between two groups of MLD and LL was observed 6 months after operation（P 0.05）,and there was significant deviation of RR in 2 groups.Conclusion For patients with coronary heart disease after PCI operation,the use of Cilostazol besides Aspirin and Clopidogrel can prevent thrombosis,the late lumen loss and effectively decrease restenosis rate.
出处
《中国医药导报》
CAS
2012年第27期66-67,70,共3页
China Medical Herald
关键词
经皮冠状动脉介入
抗血小板治疗
疗效
Percutaneous coronary intervention
Antiplatelet therapy
Efficacy
