摘要
目的观察依达拉奉对急性脑梗死患者神经功能及血清超敏C反应蛋白(hs-CRP)水平的影响。方法将160例急性脑梗死患者随机分为依达拉奉组(n=80)、胞磷胆碱钠组(n=80)。两组分别在常规治疗的基础上加用依达拉奉、胞磷胆碱钠,治疗时间均为14 d。两组均于治疗前后做神经功能评定(采用NIHSS量表),同时测定血清hs-CRP水平,并与健康对照组比较。结果①入院时急性脑梗死患者血清hs-CRP水平明显高于对照组(P<0.01);依达拉奉组与胞磷胆碱钠组血清hs-CRP水平及NIHSS评分差异无统计学意义。②入院14 d后,两组脑梗死患者血清hs-CRP水平均较入院时降低(P<0.05),但仍高于对照组,依达拉奉组的血清hs-CRP水平较胞磷胆碱钠组进一步降低(P<0.05);两组急性脑梗死患者NIHSS评分均较各自入院时降低(P<0.05),依达拉奉组的NIHSS评分较胞磷胆碱钠组进一步降低(P<0.05)。结论依达拉奉是一种有效的自由基清除剂,可明显降低急性脑梗死患者血清hs-CRP水平,在脑保护及促进神经功能恢复等方面优于胞磷胆碱钠。
Objective To explore the effect of edaravone on neurological function and serum hs-CRP levels in acute cerebral infarction patients. Methods 160 acute cerebral infarction patients were randomly divided into edara- vone group （n = 80）and citicoline sodium group （n = 80）. On the basis of routine treatment, edaravone group was given edaravone, and citicoline sodium group was given citicoline sodium. All the patients were treated for 14 d. The nerve function of the two groups was assessed by NIHSS scale ,the serum hs-CRP levels were measured at the same time, and the results were compared with control group. Results The serum hs-CRP levels of the two groups were significantly higher than those of control group（P 〈0. 01 ）,and there was no significant difference in serum hs-CRP and NIHSS score between edaravone group and citicoline sodium group before treatment. After 14 d of admission, the serum hs- CRP levels of edaravone group and citicoline sodium group decreased（ P 〈0. 05 ） ,but still higher than those of control group, and there were significant differences between edaravone group and citicoline sodium group （ P 〈 0. 05 ） ; the NIHSS scores of edaravone group and citicoline sodium group decreased（ P 〈 0. 05 ） , and there were significant differences between edaravone group and citicoline sodium group（ P 〈 0. 05 ）. Conclusion Edaravone is a effective free radical scavenging agents,it is superior to citicoline sodium in decreasing serum hs-CRP levels, protecting brain and promoting the recovery of neurological function of acute cerebral infarction patients.
出处
《实用药物与临床》
CAS
2012年第9期541-543,共3页
Practical Pharmacy and Clinical Remedies
基金
辽宁省科技厅科技攻关计划项目(2011225020)
