摘要
本研究针对微波热消融肿瘤治疗过程中温度分布实时监测的核心问题,利用计算机模拟生物组织温度场分布,提出了基于有限元的微波消融温度场仿真方法。分别仿真了微波发射功率、作用时间及生物组织热物性参数对温度场分布的影响。研究结果表明:功率增大25%,毁损区温度平均升高20%;功率增大50%,温度升高40%;功率增大75%,温度升高60%。作用时间延长,温度场分布基本不变,但有效毁损体积增大,时间延长2倍可使毁损体积增大150%。导热系数对热疗远场区热能的扩散产生作用。经验证发现仿真结果与实验结果误差较小,证明了仿真方法的准确性。研究结果对于通过微波消融术前模拟来确定合适的发射功率和作用时间,以及制订合理的手术计划有重要的参考价值。
Real-time temperature distribution monitoring during the microwave ablation of tumor is a key problem in thermotherapy. In this paper, the tissue temperature distribution was simulated by computer and a simulation method of temperature field during microwave ablation based on finite element was proposed. The effect brought by microwave transmission power, lasted time and tissue thermal physical parameters on temperature distribution was simulated respectively. The results showed that the temperature of the entire field ascended by 20% as the microwave transmission power increased by 25%; temperature ascended by 40% as the power increased by 50% and temperature ascended by 60% as the power increased by 75%. The entire temperature field unchanged but the volume of effective lesions increased as the time prolonged, the volume increased by 150% as time prolonged two times. Thermal conductivity had effect on thermal energy spread in the far field. The accuracy of the simulation had been proved through experiments. The experimental results and simulation results were almost the same and this proved the accuracy of the simulation method. The results have great value for preoperative simulation, determination of the microwave transmission power and lasted time, formulating rational operation plan before microwave ablation thermotherapy.
出处
《生物物理学报》
CAS
CSCD
北大核心
2012年第9期763-770,共8页
Acta Biophysica Sinica
基金
高等学校博士学科点专项科研基金项目(20103218110012)
江苏省科技支撑计划项目(BE2010729)
江苏省普通高校研究生科研创新计划项目(CXZZ11_0202)
南京航空航天大学基本科研业务费(1003-56XNA 12032)~~
关键词
微波消融
温度场
功率
导热系数
Microwave ablation
Temperature field
Microwave transmission power
Thermal conductivity
