摘要
目的研究自分泌运动因子(AMFR)在乳腺癌中的表达情况及其与预后的关系。方法使用实时荧光定量PCR和免疫组化的方法对AMFR在乳腺癌中的表达情况进行研究,并进行统计分析。结果在乳腺癌和癌旁正常组织中,AMFR表达在mRNA和蛋白水平表达均有差异。免疫组化分析发现AMFR表达水平与乳腺癌肿块大小、T期、N期和M期有关,而与年龄无关。生存分析发现AMFR表达高的患者预后差,可以作为一个预后指标。结论 AMFR在乳腺癌中表达升高,其可能成为一个肿瘤治疗的新靶点和预后新指标。
Objective To investigate the relationship between the expression of autocfine motility factor receptor （AMFR） and prognosis in breast carcinoma. Methods The real-time quantitative PCR, immunohistoehemieal methods and statistical analysis methods were used to study of breast carcinoma. Results Both in AMFR mRNA level and protein level, there were expression difference between the breast carcinoma and normal breast tissues. Immunohistoehemistry analyses showed that AMFR protein expression in breast carcinoma were significantly correlated with lesions length, T stage, N stage and M stage, while connections with age were not found in breast carcinoma. The survival analysis showed that patients with high AMFR expression had a poor prognosis, and AMFR may be a prognostic indicator. Conclusion AMFR expression is elevat- ed in breast carcinoma, it may become a new target for cancer therapy and a new marker of prognosis.
出处
《中国当代医药》
2012年第28期7-9,12,共4页
China Modern Medicine
关键词
自分泌运动因子(AMFR)
乳腺癌
表达
预后
Autocrine motility factor receptor （AMFR）
Breast carcinoma
Expression
Prognosis
