摘要
目的 :测定复方氯丙嗪中的盐酸氯丙嗪和盐酸异丙嗪二组分含量。方法 :CPA矩阵紫外分光光度法测定复方药物中的二组分含量 ,微机处理数据。结果 :优选得到的测定波长为 2 2 0、2 2 6和 2 5 4nm。盐酸氯丙嗪和盐酸异丙嗪的平均回收率分别为 99 6 %和 10 0 8% (n =5 ) ,CV不大于 3% (n =8)。结论 :在所选实验条件下用CPA矩阵法测定复方药物中的盐酸氯丙嗪和盐酸异丙嗪简便、快速、准确。
Objective:To determine chlorpromazine hydrochloride and promethazine hydrochloride content in the compound tablets of chlorpromazine. Methods: CPA matrix ultraviolet spectrophotometry was used to determine the two components in the compound tablets. The data were processed by a computer. Results:The selected wavelengths were 220, 226 and 254 nm. The average rate of recovery of chlorpromazine hydrochloride and promethazine hydrochloride was 99 6% and 100.8%( n =5), respectively, with CV not more than 3 0 %( n =8). Conclusion:Under the selected experimental condition, the CPA matrix method is simple, quick and accurate in the determination of chlorpromazine hydrochloride and promethazine hydrochloride content in the compound tablets.
出处
《南京军医学院学报》
2000年第2期89-90,共2页
Journal of Nanjing Military Medical College
关键词
CPA矩阵法
盐酸氯丙嗪
盐酸异丙嗪
含量
测定
CPA matrix method
spectrophotometry,ultraviolet
chlorpromazine hydrochloride
promethazine hydrochloride
