摘要
喹诺酮类(quinolones)药物是人工合成的含4-喹诺酮基本结构,对细菌DNA螺旋酶(DNA gyrase)具有选择性抑制作用,是一种DNA旋转酶抑制剂,干扰DNA超螺旋结构的解旋,从而阻碍DNA的复制,而呈现杀菌作用,故在分类上属慢效杀菌剂。笔者通过检索、查阅相应文献,综合归纳了喹诺酮类抗菌药物的耐药机制及其研究进展。
Quinolones is a synthetic of containing 4-quinolone as basic structure,which have selective inhibitory effect on bacterial DNA gyrase.It is a DNA gyrase inhibitor,interfering with DNA despiralization super spiral structure,preventing replication of DNA,and renders the bactericidal effect,so it is a slow effect of fungicides on the classification.This paper synthesize the mechanism of quinolone resistance and its research progress by retrieving related literature.
出处
《海峡药学》
2012年第9期8-10,共3页
Strait Pharmaceutical Journal
关键词
喹诺酮类抗菌药
耐药机制
研究进展
Quinolone antibacterial drugs
Drug-resistant mechanism
Research progress
