摘要
目的观察并分析泮托拉唑、阿莫西林和甲硝唑联合治疗幽门螺杆菌阳性消化性溃疡的临床疗效,为临床治疗方案提供参考依据。方法将120例患者根据入选先后顺序进行随机分组,随机分为观察组(给予泮托拉唑、阿莫西林和甲硝唑联合治疗,n=60例)和对照组(给予泮托拉唑,60例),对比两组的疗效及并发症,以及随访3,6,12个月后对比其复发率情况。结果两组患者年龄、性别、病程等临床资料比较,差异无统计学意义(P>0.05),观察组的总有效率明显高于对照组(P<0.05),观察组随访3个月和12个月的复发率明显低于对照组(P<0.05)。结论泮托拉唑、阿莫西林和甲硝唑联合治疗幽门螺杆菌阳性消化性溃疡疗效确切、并发症少,复发率低,值得临床推广应用。
Objective To observe and analyze pantoprazole, amoxicillin and metronidazole treatment of Helieobacter py- lori-positive peptic ulcer clinical efficacy,and to provide a reference for the clinical treatment programs. Methods 120 patients with Helicobacter pylori-pesitive peptic ulcer were randomly divided into two groups （ given pantoprazole, amoxicillin and metronidazole combi- nation therapy, n =60） and control group （given pantoprazole, 60 cases） from January 2008 -2010 in January in our hospital,and to compare the efficacy and complications both two groups, and after following 6, 12 months , and tocompare the recurrence rate. Results The total effec- tive observation group was significantly higher （P 〈 0.05 ）, the observation group were followed up 3 months and 12 month recurrence rate was significantly lower than the control group （P 〈 0. 05）. Conclusion Pantoprazole, amoxicillin and metronidazole treatment of Helicobacter pylori-positive peptic ulcer efficacy, fewer complications, recurrence rate, worthy of clinical application.
出处
《四川医学》
CAS
2012年第9期1635-1636,共2页
Sichuan Medical Journal
