摘要
目的 探讨幽门螺杆菌 (HP)感染、抑癌基因P5 3与胃癌发病的关系。方法 用快速尿素酶试验及改良Giemsa染色方法检测HP感染 ,用免疫组化LSAB法检测正常胃粘膜、胃癌等组织中P5 3蛋白。结果 萎缩性胃炎伴肠化组与胃癌组 ,HP( +)患者中P5 3蛋白表达率显著高于HP( -)者 (P <0 .0 5 )。结论 HP感染致野生型P5 3基因失活可能是HP致癌机制之一 ,P5
? Objective To explore the role of HP infection and dysfunction of wildtype P53 gene in the pathogenesis of gastric cancer.Methods HP was detected by using rapid urease test and modified Gemsa stain,LSAB immunohistochemical study on P53 protein was carried out by using monoclonal antibody (DO 1) to P53.Results There was a significant difference of HP infection between groups of chronic atrophic gastritis with intestinal metaplasia and gastric cancer.Conclusions HP infection causes dysfunction of wild type P53 gene,which may be one of carcinogenic mechanism of gastric cancer,and P53 protein may be a marker of high risk precancerous of gastric lesions. 〔
出处
《中国肿瘤临床与康复》
2000年第3期10-11,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
幽门螺旋杆菌
胃癌
P53
致癌机制
Helicobacter Pylori
P53
gastric neoplasm
carcinogenic mechanism
