摘要
目的 :对中国 5年根除HP治疗方案进行集成分析。方法 :检索、逐刊查阅 5年中文核心期刊及胃肠病学专业杂志。合并相同方案 ,对超过所有HP根除方案平均根除率以上的独立方案进行根除率、副作用、疗程、费用效果的比较。结果 :铋剂与两种抗菌药联用 ,其ER接近或超过 85 % ;抑酸剂 (PPI、H2 RA)与两种抗菌药联用 ,其ER接近或超过90 % ,但费用较高。无论何种方案 ,疗程长 ,每日服药次数多 ,其副作用也较多。结论 :考虑费用、根除率者 ,可选择铋剂三联加H2 RA的四联方案 ;若考虑根除率、副作用、疗程者可选择PPI三联 1周方案 ;若上述四者都考虑者 ,可选择含痢特灵。
Purpose: This study, by means of meta analysis, provides an overview of different therapy regiments in eradicating helicobacter pylori (HP) in China. Method: Retrieving and consulting all five years. Chinese core magazines about gastroenterology, we have combined the similar therapies. Meanwhile, as to the independent therapies beyond the avgrage eradication rates (ER) of all HP eradication therapies,we have also made a comparison among ER, side effects,treatment course and cost and effective ratio. Results: When bismuth and PPI, H 2RA are used with two sorts of antibiotics respectively, the former's ER is near of beyond 85%, and the latter's near or beyond 90%, but with higher cost.Either needs a long treatment period,several times to take medicine a day with more side effects. Conclusion: Bismuth*.based triple of multiple (with H 2RA) therapies are for high efficiency and low cost; one*.week PPI*.based triple therapies for small side effects, short period as well as high efficiency; bismuth*.based triple (with furazolidone clarithromycin) therapies for the four factors above.
出处
《临床消化病杂志》
2000年第3期99-101,共3页
Chinese Journal of Clinical Gastroenterology
