摘要
泛素蛋白酶体途径由泛素、蛋白泛素化相关酶、26S蛋白酶体等成分组成,通过高度有序的降解过程,将细胞内错误折叠、衰老、损伤、突变的蛋白和修饰酶等分解成小分子肽,维持胞内蛋白质水平。目前发现,一次运动可引起骨骼肌途径活性升高,而重复运动可以降低途径活性,其机制尚不明确,大致可通过不依赖途径的信号通路(FOXO,p38)和依赖途径的信号通路(MyoD,NF-κB)上调可诱导的途径成分(泛素、E2/E3、蛋白酶体亚基),激活途径,引起蛋白质降解,但还需要更进一步去证实。
Components of ubiquitin-proteasome pathway（UPP） include ubiquitin,protein ubiquitination enzymes and 26S proteasome.The misfolding,aging,damage,mutation protein,and modification enzymes broke into small peptides through its highly ordered process,which maintain the intracellular protein level.The Activity of UPP could be increased in skeletal muscle after once exercise,but could be decreased after repetitive exercises.The mechanism is not clear.It could act via pathway independent signals（FOXO,p38） and pathway dependent signals（MyoD,NF-κB） to upregulate inducible pathway elements（ubiquitin,E2/E3 proteins and proteasome subunits）,to active pathway,which cause protein degradation.But the detailed regulatory mechanism requires further study.
出处
《北京体育大学学报》
CSSCI
北大核心
2012年第9期85-91,139,共8页
Journal of Beijing Sport University
基金
浙江省自然科学基金课题(LY12C11002)
温州医学院科研启动基金课题(QTJ09018)
关键词
泛素蛋白酶体途径
运动
骨骼肌
研究进展
ubiquitin-proteasome pathway
movement
skeletal muscle
research progress
